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. 2019 Mar 1;38:110. doi: 10.1186/s13046-019-1103-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — HOXD-AS1/miR-186-5p/PIK3R3 is a clinically relevant pathway. a Pearson correlation showing significant inverse correlation between HOXD-AS1 and miR-186-5p in 200 EOC tissues. b Pearson correlation showing significant inverse correlation between miR-186-5p and PIK3R3 in 200 EOC tissues. c Pearson correlation showing significant positive correlation between HOXD-AS1 and PIK3R3 in 200 EOC tissues. d RNA ISH assay of HOXD-AS1, miR-186-5p, PIK3R3 in HOXD-AS1 high expression ovarian cancer sample and HOXD-AS1 low expression ovarian cancer sample. e, f Kaplan Meier survival curve showing significantly poorer progression-free (e) and overall (f) survival in patients who showed high HOXD-AS1, low miR-186-5p and high PIK3R3 compared to patients who showed the reciprocal expression of these three factors. g Diagram summarizing the mechanism of action of HOXD-AS1/miR-186-5p/PIK3R3 on EMT in EOC cells