Table 3.
Methylation ratios of CpG sites and Fisher’s exact P values for the five selected genes
| Gene | TH | YH | TL | YL | P-value in TH/YH | P-value in TL/YL | P-value in TH/TL | P-value in YH/YL | |
|---|---|---|---|---|---|---|---|---|---|
| BCKDHB | Methylated | 113 | 97 | 108 | 96 | 0.0029 | 0.0457 | 0.3329 | 1.0000 |
| Unmethylated | 7 | 23 | 12 | 24 | |||||
| Methylated ratio | 0.9417 | 0.8083 | 0.9000 | 0.8000 | |||||
| EPHX2 | Methylated | 133 | 146 | 129 | 148 | 0.3200 | 0.0500 | 0.5200 | 0.9100 |
| Unmethylated | 62 | 54 | 70 | 52 | |||||
| Methylated ratio | 0.6821 | 0.7300 | 0.6482 | 0.7400 | |||||
| GOT2 | Methylated | 104 | 108 | 96 | 96 | 0.0300 | 0.2463 | 1.0000 | 0.5085 |
| Unmethylated | 0 | 6 | 0 | 3 | |||||
| Methylated ratio | 1.0000 | 0.9474 | 1.0000 | 0.9697 | |||||
| RXRG | Methylated | 279 | 295 | 268 | 244 | 0.0160 | 0.7000 | 1.05E-05 | 0.0970 |
| Unmethylated | 27 | 52 | 73 | 62 | |||||
| Methylated ratio | 0.9118 | 0.8501 | 0.7859 | 0.7974 | |||||
| UBD | Methylated | 75 | 66 | 62 | 71 | 0.0483 | 0.1301 | 0.0098 | 0.3677 |
| Unmethylated | 5 | 14 | 16 | 9 | |||||
| Methylated ratio | 0.9375 | 0.8250 | 0.7949 | 0.8875 |