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. 2019 Feb 11;116(9):3594–3603. doi: 10.1073/pnas.1821638116

Fig. 6.

Fig. 6.

ForA−/E−/H− and racE− mutants form multiple and faster protruding fronts. (A) Gallery with stills from a phase-contrast time-lapse series of randomly migrating WT and mutant cells in unconfined settings corresponding to Movie S5 shows the recurring formation of multiple fronts (white arrow heads) in ForA−/E−/H− and racE− mutants. Time is in seconds. (Scale bar, 5 µm.) (B) Quantification of the average number of protruding fronts in migrating WT and mutant cells as shown in A. (C) Quantification of the ratio of protrusion area over total cell area in WT and indicated mutant cells. Error bars represent standard error of the mean. n.s., not significant; **P < 0.01 by Mann–Whitney rank sum test. (D) Average protrusion velocities of fronts in WT and mutant cells. Boxes include 50% and whiskers 80% of all measurements, and dots represent the 5th/95th percentile. n.s., not significant; ***P < 0.001 by Mann–Whitney rank sum test. n, number of cells analyzed.