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. 2019 Feb 12;116(9):3695–3702. doi: 10.1073/pnas.1813006116

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Copyright © 2019 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — The expression of EZH2 and H3K27me3 in SSc fibroblasts and ECs. (A) EZH2 mRNA levels were significantly elevated in fibroblasts from diffuse cutaneous SSc patients compared with healthy fibroblasts, but not in limited cutaneous SSc fibroblasts. EZH2 protein levels (B) and H3K27me3 levels (C) were significantly increased in diffuse cutaneous SSc fibroblasts compared with healthy controls. (D) EZH2 mRNA levels were significantly lower in diffuse cutaneous SSc ECs compared with healthy ECs. (E) EZH2 protein levels were significantly higher in diffuse cutaneous SSc ECs compared with healthy ECs. (F) The expression of H3K27me3 was not significantly different between diffuse cutaneous SSc ECs and healthy controls. Results are expressed as mean ± SD. The Mann–Whitney U test was performed, and *P < 0.05 was considered significant.