Table 1.

The expression of genes after EZH2 inhibition by DZNep (5 μM, 48 h) in diffuse cutaneous SSc fibroblasts

Gene	Expression fold change vs. control (n = 7 patient pairs)	P value
ACTA2	0.88 ± 0.21	0.18
PPARG	1.09 ± 0.40	0.58
FLI1	0.72 ± 0.25	0.01
DNMT1	0.83 ± 0.16	0.01
DNMT3A	0.70 ± 0.25	0.01
MECP2	0.78 ± 0.22	0.02
ALDH7A1	0.91 ± 0.27	0.36
CCNY	0.69 ± 0.14	0.002
CSRP2	0.73 ± 0.25	0.02
EPG5	0.80 ± 0.19	0.048
ZBTB20	0.70 ± 0.31	0.048
IL7	0.66 ± 0.11	0.001
LRRC16A	0.79 ± 0.16	0.005
SELPLG	1.70 ± 0.57	0.007

Data are expressed as fold change vs. PBS-treated cells (mean ± SD).