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. 2019 Feb 7;116(9):3604–3613. doi: 10.1073/pnas.1815126116

Fig. 5.

Fig. 5.

AhR−AREG axis regulates peripheral monocyte count in mammary tumor-bearing animals. (A) Absolute number of CD11b positive (CD11b+) monocytes in the peripheral blood of wild-type (WT) and KBP tumor-bearing mice (n = 5 per group). (B) Absolute number of CD11b+ monocytes in mice bearing mammary tumors derived from EV-, sgAhr-, or sgAreg-transfected KBP cells (n ≥ 5 per group). (C) Absolute numbers of the indicated subpopulations among CD11b+ cells in mice bearing EV, sgAhr, or sgAreg KBP tumors (n ≥ 5 per group). (D) Levels of indicated chemokines in cultured KBP cells expressing EV, sgAhr, or sgAreg vectors (n = 4 per group). (E) Positive correlation between CCL5, CXCL1, and CXCL2 mRNA levels and the ROS gene signature in the TCGA human basal-like BC dataset. See Materials and Methods for details. (F) Positive correlation between monocytic lineage cell count and the ROS gene signature in the TCGA human basal-like BC dataset. See Materials and Methods for details. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.