Table 5.
Pharmacokinetics parameters of THC and rimonabant in Wistar rats.
| Parameter | THC(Inhalation) | Rimonabant(i.p) |
|---|---|---|
| Dose | 0.05 mg/kg | 3 mg/kg |
| T1/2 (h) | 3.7 ± 1.3 | 5.4 ± 0.85 |
| AUC0-t(h*ug/L) | 12.2 ± 3 | 308.15 ± 55 |
| AUCinf(h*ug/L) | 13.9 ± 3.8 | 457.6 ± 86 |
| CL and CL/F**(L/h) | 1.1 ± 0.26 | 2.0 ± 0.3** |
| Vss (L) | 3.9 ± 2.07 | - |
| Tmax (h) | - | 0.2 ± 0.07 |
| Cmax (ng/mL) | - | 88.6 ± 5.64 |
Abbreviations: Cmax, maximum concentration achieved in plasma; Vss, Volume of distribution at steady state; AUC0-t, Area under the curve from 10 min post smoke exposure to 10 h; AUCinf, Area under the curve from 10 min post smoke exposure to infinity; CL, Clearance; t1/2, Terminal half-life; Each value represents mean ± SD**, indicating apparent clearance.