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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Small. 2018 Oct 4;14(44):e1802563. doi: 10.1002/smll.201802563

Figure 6. Spatially targeted doxorubicin release from thermally sensitive liposomes.

Figure 6.

(a) The cell viability curve for doxorubicin-loaded liposomes exposed to the AMF within the targeting region of the device is shifted left compared to liposomes at the edge. The concentration of doxorubicin-loaded liposomes exposed to the device at the center and edge are matched. Therefore, the total doxorubicin concentration is similarly matched between the center and edge, and any difference between cell viability at each concentration is due to differences in AMF-induced doxorubicin release between the center and the edge of the device. There is no decrease in cell viability observed when using blank liposomes loaded with PBS, or when using PBS only, either at the center or the edge. (b) Doxorubicin-loaded liposomes exposed to the AMF at the edge of the device have an IC50 of 4.44 ± 0.87 μM, while the same liposomes exposed to the AMF at the center targeting region of the device have an IC50 of 1.75 ± 0.37 μM; p = 0.0078. This corresponds to a therapeutic index of > 2.5 in Huh7 hepatocellular carcinoma cells. n = 3.