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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Cornea. 2019 Mar;38(3):352–359. doi: 10.1097/ICO.0000000000001823

Figure 5. The ROCK inhibitor Y27632 and cryoinjury decreased IOP in the eyes of normal dogs.

Figure 5.

The central corneal endothelium was removed by transcorneal freezing using an 8 mm steel probe immersed in liquid nitrogen then applied to the cornea of OD for 20 seconds (OS remained unwounded); 10 mM of ROCK inhibitor Y27632 (n = 3 dogs) or PBS control (n = 3 dogs) was applied topically to both eyes 6 times daily for 7 days after cryoinjury, then 4 times for the remaining 49 days. (A) The Y27632 versus PBS treated eyes had a significantly lower IOP at day 3 in eyes without cryoinjury. (B) A significant decrease in IOP was observed immediately after cryoinjury OD in the Y27632 treated groups. The P values were determined by a Student’s t-test, *P < 0.05.