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Description of LOX Isoforms Discussed in This Review
| Lipoxygenase Protein Name |
Human Gene |
Mouse Gene |
Products Forms from AA Metabolism |
Term Used in This Review |
|---|---|---|---|---|
| Leukocyte-type 12- LOX (15-LOX1 for human, 12/15-LOX for mouse |
ALOX15 | Alox15 | Human protein produces 10% 12(S)-HETE/90% 15(S)-HETE; Mouse protein produces 90% 12(S)-HETE/10% 15(S)- HETE |
12/15-LOX |
| Platelet-type 12- LOX |
ALOX 12 | Alox12 | Human and mouse proteins are functionally similar, and produce 12(S)-HETE |
12-LOX |
