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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Cancer Res. 2019 Jan 23;79(5):905–917. doi: 10.1158/0008-5472.CAN-18-1261

Figure 1.

Figure 1.

SB-induced medulloblastoma and CNS-PNET resemble human tumors.

A, Macroscopic images of normal brain and brains with SB-induced cerebellar medulloblastoma and CNS-PNET in the cerebral cortex and olfactory bulbs. T=tumor. B, Medulloblastoma and CNS-PNET frequency across genetic backgrounds. C, Upper panels: medulloblastoma H&E. i, Rosettes (arrows), mitotic nuclei (arrowheads). Primary medulloblastoma (T) with leptomeningeal spread (LS). Lower panels: medulloblastoma IHC. D, Upper panels: CNS-PNET H&E. Cerebral cortex (ctx), hippocampal formation (hpf), dentate gyrus (dg). Inset: CNS-PNET sagittal section, olfactory bulb (arrow). ii, Bulk tumor with rosette formations (arrows) and mitotic nuclei (arrowheads). iii, Tumor cell parenchyma infiltration. Lower panels: CNS-PNET IHC. Scale bars = 50 μm.