Figure 2.

SB-induced tumors resemble human medulloblastoma and CNS-PNET transcriptionally.

A, Hierarchical clustering of medulloblastoma transcription profiles(6). Red and green boxes denote transcripts in SHH and group 3/4, respectively (P-value <0.002, Fisher’s Exact Test (FET)). SHH, WNT, and group 3/4 designation indicated with red, black, and green toebars, respectively. B, Hierarchical clustering of CNS-PNET transcription profiles(6). Blue boxes denote transcripts in CNS NB-FOXR2 (P-value <1.0e-8, FET). CNS NB-FOXR2 and non-FOXR2 CNS-PNET designation are shown with blue and black toebars, respectively. Log-transformed and mean-centered data with variance >0.5 for murine RNA-Seq datasets and >2.0 for human array datasets were clustered using average linkage clustering. Clusters systematically identified with node correlation >0.2.