Table 3:
Overall response rate (CR, CRi, PR, HI) by baseline characteristics.
| No Response (n=47) | Response (n=23) | p-value | |||
|---|---|---|---|---|---|
| N | % (mean) | N | % (mean) | ||
| Age | 0.79 | ||||
| <60 | 9 | 19 | 5 | 22 | |
| >/=60 | 38 | 81 | 18 | 78 | |
| Age | 0.67 | ||||
| <70 | 23 | 49 | 10 | 43 | |
| >/=70 | 24 | 51 | 13 | 57 | |
| Salvage status | 0.20 | ||||
| S1 | 19 | 40 | 13 | 57 | |
| >S1 | 28 | 60 | 10 | 43 | |
| Salvage status | 0.12 | ||||
| S1/S2 | 34 | 72 | 21 | 91 | |
| >S2 | 13 | 28 | 2 | 9 | |
| Diagnosis | 0.54 | ||||
| AML - de novo | 25 | 53 | 14 | 61 | |
| Secondary AML | 22 | 47 | 9 | 39 | |
| Prior ASCT | 0.52 | ||||
| Yes | 10 | 21 | 3 | 13 | |
| No | 37 | 79 | 20 | 87 | |
| Prior HMA | 0.01 | ||||
| Yes | 35 | 74 | 10 | 57 | |
| No | 12 | 26 | 13 | 43 | |
| Cytogenetic | 0.13 | ||||
| Diploid | 13 | 28 | 12 | 52 | |
| miscellaneous | 16 | 34 | 5 | 22 | |
| −5/−7/complex | 18 | 38 | 6 | 26 | |
| TP53 | 0.23 | ||||
| Negative | 34 | 72 | 20 | 87 | |
| Positive | 13 | 28 | 3 | 13 | |
| IDH1 | 0.99 | ||||
| Negative | 43 | 91 | 21 | 91 | |
| Positive | 4 | 9 | 2 | 9 | |
| IDH2 | 0.46 | ||||
| Negative | 42 | 89 | 19 | 83 | |
| Positive | 5 | 11 | 4 | 17 | |
| RAS | 0.14 | ||||
| Negative | 43 | 91 | 18 | 78 | |
| Positive | 4 | 9 | 5 | 22 | |
| ASXL1 | 0.03 | ||||
| Negative | 43 | 91 | 16 | 70 | |
| Positive | 4 | 9 | 7 | 30 | |
| BM BL>/=30 | |||||
| No | 19 | 40 | 12 | 52 | 0.35 |
| Yes | 28 | 60 | 11 | 48 | |
| BM BL>/=20 | 0.02 | ||||
| No | 8 | 17 | 10 | 43 | |
| Yes | 39 | 83 | 13 | 57 | |
| BM BL>/=10 | 0.10 | ||||
| No | 3 | 6 | 5 | 22 | |
| Yes | 44 | 94 | 18 | 78 | |
| WBC>10 | 0.03 | ||||
| No | 34 | 72 | 22 | 96 | |
| Yes | 13 | 28 | 1 | 4 | |
| PLT>50 | 0.43 | ||||
| No | 33 | 70 | 14 | 61 | |
| Yes | 14 | 30 | 9 | 39 | |
| BM pretherapy CD3+ | 23 | (17.56) | 19 | (32.47) | 0.042 |
| PB pretherapy CD3+ | 22 | (21.83) | 18 | (45.07) | 0.0058 |
Abbreviations: N: number, ORR: overall response rate, HMA: hypomethylating agent, SCT: Allogeneic stem cell transplant, BM: Bone marrow, PB: peripheral blood.