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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Pediatr Res. 2018 Oct 26;85(4):511–517. doi: 10.1038/s41390-018-0215-5

Table 1.

Study Design: treatment dosing and sample sizes by study outcome

OUTCOME N TREATMENT DOSING
Pharmacokinetic Studies
IV vs IP Dosing 4/group 5mg/kg IP x2 (t=0 and 60 min post-ROSC)
IP + Infusion Pump 6/group 5mg/kg IP (t=0) + 0.08mg/h continuous
Edema
3 h 6/group 5mg/kg IP x2 (t=0 and 60 min post-ROSC)
6 h 6/group 5mg/kg IP + 0.08mg/h continuous
24 h 6/group 5mg/kg IP + 0.08mg/h continuous
NDS and Histology 6/group 5mg/kg IP + 0.08mg/h continuous

Abbreviations: IV, intravenous; IP, intraperitoneal; mg, milligram; kg, kilogram; ROSC, return of spontaneous circulation