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Increased on-treatment TIL clonality and T-cell fraction in tumor samples correlate with clinical benefit (P = 0.002, OR = 30). Changes in TIL clonality and T-cell fraction were determined by subtracting values determined at baseline from those determined in week 13 biopsies. P value was obtained from a Fisher’s exact test of CR/PR versus SD/PD comparing the top right quadrant to the remaining three quadrants.
