Fig. 6.

Effect of CR on DNA methylation. The CpG sites differentially methylated between old mice fed ad libitum and CR is shown. The CpG sites that change with age in the ad libitim fed mice that were prevented by CR are shown in green. The changes in methylation induced by CR that did not change with age in ad libitum fed mice are shown in red. Approximately 70% of the changes in DNA methylation induced by CR are age independent, i.e., do not occur with age in mice fed ad libitum. Data taken from Hadad et al. (2018).