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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Pharmacol Ther. 2018 Nov 9;195:172–185. doi: 10.1016/j.pharmthera.2018.11.001

Table 5.

List of studies investigating the effect of caloric restriction on DNA methylation.

Reference Animal Sex Method Tissue Length of CR* Age Studied* CpG Sites Studied % Sites Altered by CR
Kim et al. (2016) Rat (Sprague Dawley) Male MeDIP-Seq Kidney 1 25 Unknown Unknown
Cole et al. (2017) Mice (UM-HET3) Female WGBS Liver 18 22 ~42 million ~3%**
Hahn et al. (2017) mice (c3b6f1) Female BS-Seq Liver 24 27 ~29 million ~18%
Hadad et al. (2018) Mice (C57BL/6) Male BOCS Hippocampus 21 24 ~2 million ~35%
*

Given in months.

**

This percentage is based on differentially methylated regions and not specific CpG sites.