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. 2019 Feb 26;7(4):419–430. doi: 10.12998/wjcc.v7.i4.419

Table 3.

Human epidermal growth factor receptor 2 immunohistochemistry and dual color in situ hybridization results in Human epidermal growth factor receptor 2-immunoreactive cases (n = 8)

Case No. Formalin HER-2 IHC score; P = 1.000 (6 h-48 h vs 1 wk)1
DISH; HER2/CEP17ratio (average HER2 copy number); P = 0.6989 (6 h-48 h vs 1 wk)1
Final assessment
6 h 24 h 48 h 1 wk 6 h 24 h 48 h 1 wk
12 10% F 3+ 3+ 3+ 3+ 11.4 (33.7) 10.9 (28.5) 7.1 (20.4) 4.8 (17.4) +
14 10% F 1+ 2+ 0 0 1.2 (3.0) 1.3 (3.3) 1.3 (2.2) 1.3 (2.2) -
20 10% F 2+ 0 0 0 0.8 (2.1) 1.2 (2.8) 1.3 (2.1) 1.3 (2.0) -
22 10% F 1+ 1+ 2+ 2+ 1.6 (3.4) 1.9 (4.4) 2.1 (2.5) 2.1(2.8) +
25 10% NBF 0 1+ 2+ 1+ 1.0 (1.9) 1.1 (2.2) 1.8 (3.1) 1.4 (2.5) -
26 10% NBF 2+ 2+ 2+ 2+ 2.6 (5.2) 3.7 (6.5) 3.5 (6.6) 3.3 (5.7) +
27 10% NBF 2+ 1+ 1+ 3+ 1.1 (2.9) 1.4 (2.8) 1.3 (2.1) 2.2 (4.9) +
31 10% NBF 3+ 3+ 3+ 3+ 4.7 (19.8) 6.7 (21.2) 4.7 (15.7) 7.2 (21.2) +
1

Simultaneous tests for linear hypotheses based on a linear mixed effects model.

F: Formalin; NBF: Neutral buffered formalin; DISH: Dual color in situ hybridization; HER-2: Human epidermal growth factor receptor 2; PD-L1: Programmed death-ligand 1.