Table 1.
Clinical phenotype in three fever-associated acute liver failure episodes
| Age 3 y 6 mo | Age 6 y 3 mo | Age 8 y 5mo | Range | |
| Febrile illness before ALF | Yes | Yes | Yes | |
| Using antipyretics before ALF | Yes | No | Yes | |
| Duration | > 4 mo | > 1 mo | > 1 mo | |
| Max TB (μmol/L) | 504.0 | 305.7 | 554.0 | 5.1-17.1 |
| Max DB (μmol/L) | 288.0 | 125.0 | 264.7 | 0-6.0 |
| Max ALT (IU/L) | 414 | 1865 | 881 | 0-40 |
| Max AST (IU/L) | 2050 | 4900 | 1648 | 15-60 |
| Max GGT (IU/L) | 117 | 39 | 70 | 7-50 |
| Max PT (s) | 24.9 | 29.5 | 26.7 | 11.0-14.5 |
| Hepatomegaly | Yes | Yes | Yes | |
| Splenomegaly | No | No | Yes | |
| Additional features | Antipyretic- induced hepatopathy diagnosed | Multi-organ involvement1 | Multi-organ involvement2 |
1
Multi-organ involvement: Acute liver failure, severe acute pancreatitis, bilateral pneumonia, alimentary tract hemorrhage, and septic shock.
2
Multi-organ involvement: Acute liver failure, bronchopneumonia, moderate anemia, ventricular premature beats, hypokalemia, hyponatremia, and bilateral femoral abnormalities. ALF: Acute liver failure; TB: Total bilirubin; DB: Direct bilirubin; ALT: Alanine transaminase; AST: Aspartate transaminase; GGT: gamma-glutamyl transpeptidase; PT: Prothrombin time; Max: Maximum.