Figure 1.

Synthesis diagram of the multi-targeting drug delivery micelle with hesperetin embedded. The multi-targeting micelles are composed of NIPAAm, DMAAm, and UA. The micelles are grafted CM-Dextran/Fe₃O₄ for magnetic manipulation. The inflammatory drug hesperetin are embedded into the micelles. Local inflammation area with relatively lower pH value and higher temperature led to the release of drug from the micelles. Target release to the inflammation area could be achieved by external magnetic field.