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. 2019 Feb 25;10:147. doi: 10.3389/fneur.2019.00147

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Copyright © 2019 Lindner, Gosewisch, Eilles, Branner, Krämer, Oos, Wolf, Ziegler, Bartenstein, Brandt, Dieterich and Zwergal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma levels of EGb 761 substrates and correlation to behavioral scores. (A) Before UL, plasma levels of ginkgolide A and bilobalide were significantly higher in the EGb 761/EGb 761 group A and B compared to Controls. Ginkgolide B levels were higher in the group A compared to group C. Fifteen days post UL, ginkgolide A and B levels were significantly higher in the EGb 761/EGb 761 75 mg/kg group A and the Control/EGb 761 group D compared to the 18.75 mg/kg group C. Additionally, gingkolide B levels were higher in the EGb 761/EGb 761 75 mg/kg group A compared to the 37.5 mg/kg group B. Levels of bilobalide were significantly higher in the EGb 761/EGb 761 75 mg/kg group A compared to the group C. (B) Locomotor velocity after UL moderately but significantly increased over time with higher plasma levels of ginkgolide B (R = 0.46, p = 0.0068). Asterisk indicates a level of significance in Kruskal-Wallis post hoc test of p < 0.05.