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. 2019 Feb 25;10:134. doi: 10.3389/fphys.2019.00134

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Copyright © 2019 Ott, Kaufmann, Granzow, Hinderhofer, Bartram, Theiß, Seitz, Paramasivam, Schulz, Moog, Blum and Evers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pedigree and MRI scans. (A) Pedigree of patient family. Black symbol, affected individual; White symbols, unaffected individuals. (B–H) MR imaging of the patient at age 2 years and 6 months. Sagittal (B) and axial (C–H) images showed polymicrogyria in the parietal and temporal region (C,D) and hypoplasia of vermis cerebellum (B,E–H). Axial MR images of cerebellum and brainstem (E–H) showed a mild “molar tooth sign” (marked with white arrows in F–H) due to a deep interpeduncular fossa, prominent and elongated superior cerebellar peduncles and a hypoplastic cerebellar vermis. (I–L) Corresponding MR images of a healthy control individual.