Table 1.
Characteristics of the TMA patients and healthy controls.
| Characteristics analyzed | TMA | Healthy controls | Result of statistical comparison |
|---|---|---|---|
| Number of individuals enrolled | 171 | 69 | NA |
| Age | 35.2 (7.7–56.9) | 33.0 (18.7–41.0) | P = 0.608 |
| Sex (male/female in %) | 43/57 | 48/52 | NA |
| First acute episode (%) | 93.6 | NA | NA |
| 31-days mortality (%) | 11.7 | 0 | NA |
| Complement C3 < 0.9 g/L (%) | 49.7 | 0 | NA |
| Complement FH < 250 mg/L (%) | 25.7 | 0 | NA |
| LABORATORY PARAMETERS INDICATIVE OF ONGOING TMA | |||
| Red blood cell count (109/L) | 2.9 (2.6–3.4) | 4.9 (4.6–5.2) | p < 0.001 |
| Hemoglobin (g/L) | 85 (75–97) | 141 (134–152) | p < 0.001 |
| Platelet count (109/L) | 46 (22–75) | 262 (235–309) | p < 0.001 |
| Lactate dehydrogenase (U/L) | 1,819 (893–3,051) | Not done | NA |
| Creatinine (μmol/L) | 188 (86–320) | 71 (64–78) | p < 0.001 |
| Carbamide (mmol/L) | 16.9 (10.9–25.9) | 4.5 (3.8–5.6) | p < 0.001 |
| PENTRAXIN LEVELS AND WHITE BLOOD CELL PROFILE | |||
| PTX3 level (μg/L) | 5.19 (2.08–13.17) | 1.08 (0.75–1.66) | p < 0.001 |
| CRP level (mg/L) | 16.9 (4.3–72.0) | 1.4 (0.8–2.0) | p < 0.001 |
| White blood cell count (G/L) | 10.4 (7.1–15.3) | 6.5 (5.4–7.9) | p < 0.001 |
| Absolute neutrophil count (G/L) | 7.1 (4.8–12.4) | 4.0 (3.0–4.7) | p < 0.001 |
| Absolute lymphocyte count (G/L) | 1.4 (0.8–2.6) | 2.0 (1.8–2.4) | p < 0.001 |
| COMPLEMENT PARAMETERS | |||
| ADAMTS13 activity (%) (Reference range: 67–147%) | 38 (17–54) | Not done | NA |
| Classical pathway activity (CH50/ml) | 57 (45–71) | 70 (62–77) | p < 0.001 |
| Alternative pathway activity (%) | 86 (56–101) | 101 (78–117) | p < 0.001 |
| C3 level (g/L) | 0.90 (0.68–1.15) | 1.26 (1.18–1.47) | p < 0.001 |
| C4 level (g/L) | 0.23 (0.14–0.32) | 0.34 (0.27–0.40) | p < 0.001 |
| Factor H level (mg/L) | 390 (245–513) | 560 (462–692) | p < 0.001 |
| Factor I level (%) | 98 (81–123) | 102 (92–108) | p = 0.192 |
| Factor B level (%) | 98 (73–116) | 101 (91–113) | p = 0.791 |
| C1q level (mg/L) | 87 (56–112) | 100 (80–124) | p = 0.020 |
| sC5b-9 level (ng/mL) (Reference range: 110–252 ng/mL) | 352 (265–517) | Not done | NA |
| C3a level (ng/mL) (Reference range: 70–270 ng/mL) | 171 (120–259) | Not done | NA |
Characteristics and laboratory data of the TMA patients and healthy controls. Data are shown as median with interquartile range, results of statistical comparison are indicated with the respective p-value of the Mann-Whitney test. ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; CRP, C-reactive protein; FH, factor H; NA, not applicable; PTX3, pentraxin-3; sC5b-9, soluble C5b-9; TMA, thrombotic microangiopathy.