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Effects of bicuculline on anxiety. Anxiety was assessed using a hole-board test in an actimeter as indicated in Section “Materials and Methods.” Total and novel head dips were quantified by the Activity monitor software and the means ± SEM of eight rats per group are represented in (A,B), respectively. Values significantly different from control rats are indicated by asterisks and from hyperammonemic rats by “a.” ∗p < 0.05, ∗∗p < 0.01; a p < 0.05.
