Table 1.
Previous studies regarding the clinical significance of 18F‐fluorodeoxyglucose positron emission tomography parameters to detect nodal metastases
| Author/year | No. patients (% ADC) | cStage (% cStage IA) | No. of occult nodal metastases (%) | Cut‐off tumor SUV max | Findings | Accuracy |
|---|---|---|---|---|---|---|
| Kaseda K/2016 | 246 (78%) | Clinical I (58%) | N1: 13 (5.3%)N2: 18 (7.3%) | 3.0 | SUVmax, tumor size, and histology were risk factors of nodal metastases | 55% (Sensitivity: 68% Specificity: 61%) |
| Lin JT/2016 | 284 (85%) | Clinical I (65%) | N2: 24 (8.5%) | 7.3 | SUVmax was risk factors of nodal metastases | 77% (Sensitivity: 50% Specificity: 79%) |
| Nakamura H/2015 | 209 (72%) | Clinical I ‐ III (44%) | Total: 28 (11%) | 3.0 | SUVmax, ly, v, and pl were risk factors of nodal metastases | 55% (Sensitivity: 82% Specificity: 51%) |
| Miyasaka Y/2014 | 265 (76%) | Clinical I (72%) | N1: 27 (10%)N2: 24 (9.0%) | 10 | SUVmax and consolidation to tumor ratio were risk factors of nodal metastases | 77% (Sensitivity: 49% Specificity: 83%) |
| Li L/2013 | 189 (78%) | Clinical I (71%) | N1: 30 (16%)N2: 14 (7.4%) | 4.3 | SUVmax and tumor size were risk factors of nodal metastases | 56% (Sensitivity: 94% Specificity: 48%) |
| Li S/2013 | 129 (83%) | Clinical I (N/A) | N1: 25 (11%)N2: 49 (22%) | 4.0 | SUVmax was a risk factor of nodal metastases | 56% (Sensitivity: 72% Specificity: 48%) |
| Li X/2013 | 144 (73%) | Clinical IA (100) | N1: 8 (5.6%)N2: 4 (2.8%) | 7.25 | SUVmax of primary tumor is not associated with occult nodal metastases | 69% (Sensitivity: 68% Specificity: 70%) |
ADC, adenocarcinoma; ly, lymphatic invasion; N1, ipsilateral hilar nodes; N2, ipsilateral mediastinal nodes; pl, pleural invasion; SUVmax, maximum standardized uptake value; v, vascular invasion.