Table 2.

Previous studies regarding prognostic significance of 18F‐fluorodeoxyglucose positron emission tomography parameters in pathological stage I non‐small cell lung cancer (>100 patients)

Author/year	No. patients (% ADC)	pStage (% pStage IA)	PET parameters	Outcome	Cut‐off value of PET parameters	Findings
Park SY/2015	248 (79%)	IA (100%)	SUVmax, MTV, TLG	OS, DFS	3.7 (SUVmax), 13.76 (TLG)	TLG was more strongly associated with OS and DFS compared to SUVmax and MTV
Ko KH/2015	145 (90%)	IA (100%)	SUVmax	DFS	2.5	MTV and TLG were significantly associated with OS and DFS
Domachevsky L/2015	181 (43%)	I – II (N/A)	SUVmax, MTV, TLG	OS	8.2 (SUVmax)	SUVmax was significantly associated with OS regardless of N‐status
Kwon WI/2015	336 (55%)	I (59%)	SUVmax	OS, TTR	3.4, 7.2, 14.2†	Risks of both OS and TTR were significantly increase as SUVmax increased
Kim DH/2014	102 (100%)	I – II (33%)	SUVmax, MTV, TLG	DFS	6.90 (SUVmax), 10.78 (MTV), 39.68 (TLG)	SUVmax, MTV, and TLG were significantly associated with DFS
Hyun SH/2013	529 (50%)	I – II (33%)	SUVmax, MTV, TLG	DFS, OS	16 (MTV), 70 (TLG)	MTV and TLG were significantly associated with OS and DFS
Shiono S/2011	356 (73%)	I (75%)	SUVmax	DFS	4.7	SUVmax was significantly associated with DFS
Agarwal M/2010	363 (63%)	I – II (61%)	SUVmax	OS	5.9	SUVmax was significantly associated with OS
Um SW/2009	145 (48%)	I (35%)	SUVmax	DFS	13.1	SUVmax was significantly associated with DFS
Kim HR/2009	107 (44%)	I (53%)	SUVmax	OS	2.4	SUVmax was significantly associated with OS
Goodgame B/2008	136 (52%)	I (57%)	SUVmax	OS	5.5	SUVmax was significantly associated with OS

^† Multiple group comparison.

ADC, adenocarcinoma; DFS, disease‐free survival; MTV, metabolic tumor volume; OS, overall survival; PET, positron emission tomography; SUVmax, standardized uptake value; TLG, total lesion glycolysis; TTR, time to recurrence.