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Severity of joint destruction at (a) all, (b) DIP, (c) PIP, and (d) MP joints in collagen-induced arthritis monkeys. The number of all joints (DIP + PIP + MP) was 384 (48 joints/monkey, n=8) in the control and MTX group and 432 (48 joints/monkey, n=9) in the ONO-5334 and ONO-5334/MTX groups.
