Figure 5.

Effect of miR-219 on forelimb movement during behavioral tests after C5 hemicontusion. (a) Compared to preinjury, the rats in the SCI group produced marked deficits in rearing performance on days 7, 10, and 14 after SCI (p < 0.001). Rats on days 10 and 14 after SCI in the antagomir-219 group exhibited a more profound decline in usage of the affected paw, whereas a significant increase on day 14 after SCI was observed in the agomir-219 group. (b) A more severe grooming deficit of the ipsilateral paw was observed after contusion injury (p < 0.001). At days 10 and 14 postinjury, animals in the antagomir-219 group achieved lower scores than did those in the SCI group, whereas only on day 14 postinjury the rats in the agomir-219 group achieved higher scores than did the SCI group. Error bars indicate SEM. ^∗p < 0.05. NC: negative control.