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. 2019 Feb 18;2019:7192798. doi: 10.1155/2019/7192798

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Copyright © 2019 Zhong-Jie Liu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ru360 or the knockdown of MCU could attenuate bupivacaine-induced mitochondrial oxidative damage and apoptosis in SH-SY5Y cell incubation with high glucose. NC: cells transfected with silencer negative control siRNA; siMCU: cells transfected with MCU siRNA; Ru360: cells pretreated with 10 μΜ Ru360 for 30 min; HG+Bup: cells cultured with 25 mM glucose for 2 days and treated with 1.0 mM bupivacaine for 6 h. (a) Mitochondrial damage was measured with JC-1. (b) Apoptotic cells (early apoptotic cells at the lower right quadrant for Annexin V-FITC-positive and PI-negative) were measured with flow cytometry. Values are the mean ± SD (n = 3); ^∗P < 0.05, ^∗∗P < 0.01.