Table 3.
Chemokines, growth factor, angiogenetic factor, and wound healing factor concentrations in aqueous humor of a control group and patients with pOT and rOT (n = 62).
| Immune mediator | Mdn concentration in patients with pOT, n = 21 (IQR) (pg/ml) | Mdn concentration in patients with rOT, n = 30 (IQR) (pg/ml) | Mdn concentration in patients in the control group, n = 11 (IQR) (pg/ml) | pOT vs control p value | rOT vs control p value | pOT vs rOT p value |
|---|---|---|---|---|---|---|
| Chemokines | ||||||
| MIP-1α | 271 (134, 412) | 157 (56.7, 451) | 0 (0, 41.2) | <0.0001 | <0.001 | 0.331 |
| MIP-1β | 396 (299, 604) | 283 (178, 593) | 218 (166, 341) | 0.023 | 0.210 | 0.153 |
| IP-10 | 5.97∗105 (7.93∗104, 9.38∗105) | 1.52∗105 (2.75∗104, 7.99∗105) | 5.75∗103 (3.17∗103, 13.0∗104) | <0.00001 | <0.0001 | 0.235 |
| Eotaxin | 925 (241, 1.32∗103) | 755 (0, 1.01∗103) | 1.95 (0, 290) | <0.001 | 0.007 | 0.302 |
| IL-8 | 280 (128, 937) | 120 (51.6, 611) | 56.5 (0, 90.2) | <0.001 | 0.009 | 0.166 |
| RANTES | 219 (61.3, 296) | 91.1 (7.4, 372) | 0 (0, 0) | <0.0001 | <0.001 | 0.366 |
| PDGF-bb | 288 (63.8, 598) | 164 (0, 419) | 0 (0, 0) | <0.001 | 0.001 | 0.378 |
| Growth, angiogenetic, and wound healing factors | ||||||
| GM-CSF | 0 (0, 169) | 0 (0, 98.7) | 0 (0, 0) | 0.036 | 0.067 | 0.639 |
| G-CSF | 513 (68.8, 1.76∗103) | 195 (5.37, 999) | 0 (0, 435) | 0.004 | 0.034 | 0.258 |
| MCP-1 | 2.13∗103 (1.14∗103, 5.45∗103) | 1.48∗103 (1.05∗103, 2.41∗103) | 958 (667, 1.34∗103) | <0.001 | 0.009 | 0.151 |
| VEGF | 1.13∗103 (394, 1.78∗103) | 908 (246, 1.85∗103) | 1.29∗103 (828, 1.68∗103) | 0.746 | 0.469 | 0.637 |
| FGF basic | 38.2 (2.87, 80.6) | 27.6 (0.67, 60.4) | 0 (0, 57.5) | 0.066 | 0.245 | 0.333 |
pOT: primary OT; rOT: recurrent OT, Mdn: median, IQR: interquartile range: significant p values are shown in bold; italic values are below LLOQ as defined by the manufacturer.