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. 2019 Feb 17;2019:1897174. doi: 10.1155/2019/1897174

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Copyright © 2019 Shuo Qiu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wound healing rate and collagen accumulation in wound tissue. (a) The remaining wound area was measured after photography. VH298-treated wounds healed much faster compared to PBS-treated wounds. Graphs represent mean ± SD (VH298-treated vs. PBS-treated) (n = 8). (b) Masson trichrome staining showed more collagen deposition (blue) in the granulation tissue (black line-circled area), in which quantitative measurement was applied, and the collagen deposition ratio was significantly increased in the VH298-treated group compared to the PBS-treated group at the early and middle stages (7 days and 14 days). Graphs represent mean ± SD (VH298-treated vs. PBS-treated) (n = 8). ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001. D: day; n.s.: not significant.