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Schematic diagram of the findings. In eosinophils (EOS), TNF-α plus IL-3 trigger stabilization and accumulation of IL-1β mRNA and IL-1β protein production. TNF-α plus IL-3 activation also leads to the production of MMP-9, which cleaves the proform of IL-1β protein into a mature and active IL-1β protein with an apparent molecular weight < 17 kDa.
