Table 3.
MYH15 polymorphisms in cases and controls.
| SNPs | Case group N | Control group N | Genetic model b | OR (95% CI) | P ∗ | P # |
|---|---|---|---|---|---|---|
| rs12638212 (A>G) | 410 | 418 | Add | 0.902 (0.721-1.129) | 0.367 | 0.682 |
| AA | 149 (0.363) | 143 (0.342) | Dom | 0.836 (0.598-1.170) | 0.297 | 0.644 |
| AG | 187 (0.456) | 197 (0.471) | All | 1.0589 (0.871-0.287) | 0.571 | 0.874 |
| GG | 74 (0.180) | 78 (0.187) | Rec | 0.925 (0.614-1.395) | 0.711 | 0.938 |
| rs9842751 (T>C) | 410 | 418 | Add | 0.887 (0.710-1.108) | 0.293 | 0.635 |
| TT | 125 (0.305) | 122 (0.292) | Dom | 0.863 (0.606-1.227) | 0.411 | 0.763 |
| TC | 197 (0.480) | 198 (0.474) | All | 0.936 (0.772-1.136) | 0.503 | 0.874 |
| CC | 88 (0.215) | 98 (0.234) | Rec | 0.839 (0.576-1.224) | 0.363 | 0.642 |
| rs7635009 (A>G) | 410 | 418 | Add | 0.779 (0.618-0.981) | 0.033 | 0.143 |
| AA | 182 (0.444) | 160 (0.383) | Dom | 0.712 (0.514-0.986) | 0.041 | 0.178 |
| AG | 178 (0.434) | 198 (0.474) | All | 1.197 (0.979-1.463) | 0.080 | 0.347 |
| GG | 50 (0.122) | 60 (0.144) | Rec | 0.731 (0.463-1.155) | 0.180 | 0.642 |
| rs2278980 (C>T) | 410 | 418 | Add | 0.958 (0.720-1.274) | 0.767 | 0.860 |
| CC | 277 (0.676) | 276 (0.660) | Dom | 0.925 (0.660-1.295) | 0.649 | 0.921 |
| CT | 117 (0.285) | 131 (0.313) | All | 1.009 (0.786-1.295) | 0.945 | 0.955 |
| TT | 16 (0.039) | 11 (0.026) | Rec | 1.119 (0.482-2.598) | 0.794 | 0.938 |
| rs1463431 (C>T) | 410 | 418 | Add | 1.000 (0.806-1.239) | 0.997 | 0.997 |
| CC | 136 (0.332) | 135 (0.323) | Dom | 1.018 (0.727-1.425) | 0.918 | 0.950 |
| CT | 182 (0.444) | 194 (0.464) | All | 0.994 (0.819-1.207) | 0.955 | 0.955 |
| TT | 92 (0.224) | 89 (0.213) | Rec | 0.976 (0.667-1.428) | 0.902 | 0.948 |
| rs4855559 (G>T) | 410 | 418 | Add | 1.033 (0.809-1.319) | 0.794 | 0.860 |
| GG | 240 (0.585) | 238 (0.569) | Dom | 0.941 (0.682-1.298) | 0.712 | 0.921 |
| GT | 130 (0.317) | 148 (0.354) | All | 0.987 (0.791-1.231) | 0.907 | 0.955 |
| TT | 40 (0.098) | 32 (0.077) | Rec | 1.455 (0.807-2.624) | 0.213 | 0.642 |
| rs9288876 (T>A) | 410 | 418 | Add | 0.747 (0.588-0.947) | 0.016 | 0.117 |
| TT | 200 (0.488) | 176 (0.421) | Dom | 0.693 (0.502-0.955) | 0.025 | 0.163 |
| TA | 171 (0.417) | 191 (0.457) | All | 0.808 (0.658-0.993) | 0.042 | 0.347 |
| AA | 39 (0.095) | 51 (0.122) | Rec | 0.669 (0.405-1.103) | 0.115 | 0.642 |
| rs936266 (C>T) | 410 | 418 | Add | 1. 058 (0.833-1.343) | 0.645 | 0.860 |
| CC | 225 (0.549) | 228 (0.545) | Dom | 0.990 (0.719-1.362) | 0.950 | 0.950 |
| CT | 141 (0.344) | 156 (0.373) | All | 0.267 (0.761-1.172) | 0.605 | 0.874 |
| TT | 44 (0.107) | 34 (0.081) | Rec | 1.379 (0.792-2.399) | 0.256 | 0.642 |
| rs7652606 (A>G) | 410 | 418 | Add | 0.932 (0.707-1.229) | 0.620 | 0.860 |
| AA | 261 (0.637) | 253 (0.605) | Dom | 0.902 (0.650-1.253) | 0.538 | 0.874 |
| AG | 131 (0.320) | 148 (0.354) | All | 1.088 (0.859-1.378) | 0.484 | 0.874 |
| GG | 18 (0.044) | 17 (0.041) | Rec | 1.026 (0.468-2.250) | 0.948 | 0.948 |
| rs2290600 (A>C) | 410 | 418 | Add | 1.045 (0.837-1.304) | 0.700 | 0.860 |
| AA | 105 (0.256) | 106 (0.254) | Dom | 1.053 (0.735-1.509) | 0.779 | 0.921 |
| AC | 202 (0.493) | 210 (0.502) | All | 0.991 (0.817-1.201) | 0.924 | 0.955 |
| CC | 103 (0.251) | 102 (0.244) | Rec | 1.068 (0.739-1.544) | 0.725 | 0.938 |
| rs1454197 (T>G) | 410 | 418 | Add | 0.756 (0.600-0.953) | 0.018 | 0.117 |
| TT | 182 (0.444) | 157 (0.376) | Dom | 0.673 (0.485-0.933) | 0.018 | 0.163 |
| TG | 178 (0.434) | 201 (0.481) | All | 0.823 (0.673-1.006) | 0.057 | 0.347 |
| GG | 50 (0.122) | 60 (0.144) | Rec | 0.731 (0.463-1.155) | 0.180 | 0.642 |
| rs12493483 (A>G) | 410 | 418 | Add | 1.155 (0.929-1.436) | 0.196 | 0.598 |
| AA | 125 (0.305) | 130 (0.311) | Dom | 1.240 (0.884-1.738) | 0.212 | 0.644 |
| AG | 190 (0.463) | 206 (0.493) | All | 0.919 (0.758-1.116) | 0.395 | 0.874 |
| GG | 95 (0.232) | 82 (0.196) | Rec | 1.188 (0.808-1.747) | 0.382 | 0.642 |
| rs10933946 (T>A) | 410 | 418 | Add | 1.154 (0.913-1.460) | 0.230 | 0.598 |
| TT | 135 (0.329) | 149 (0.356) | Dom | 1.200 (0.860-1.675) | 0.284 | 0.644 |
| TA | 207 (0.505) | 202 (0.483) | All | 1.070 (0.878-1.302) | 0.498 | 0.874 |
| AA | 68 (0.166) | 67 (0.160) | Rec | 1.213 (0.777-1.893) | 0.395 | 0.642 |
OR, 95% CI: Odds Ratio, 95% Confidence Interval. N: number of cases and controls. Values are absolute numbers (decimals) and OR, 95% CI. ∗Adjusted for sex, age, body mass index, and smoking history with logistic regression. #Corrected by false discovery rate. bAll: allelic model.
Add: additive model; Dom: dominant model; Rec: recessive model. SNPs: single nucleotide polymorphisms.