Table 4.
Haplotype analysis of MYH15 in cases and controls.
| Haplotype | Case group N | Control group N | x2 | P∗ | OR (95% CI) |
|---|---|---|---|---|---|
| A T A C C G T C A A T A T | 49.19 (0.060) | 53.03 (0.063) | 0.078 | 0.781 | 0.944 [0.629-1.417] |
| A T A C C G T C A A T G A | 245.93 (0.300) | 235.09 (0.281) | 0.925 | 0.336 | 1.121 [0.888-1.414] |
| A T A C T T T T A C T A A | 51.89 (0.063) | 53.54 (0.064) | 0.002 | 0.962 | 0.990 [0.664-1.477] |
| G C A T T G T C A C T A T | 27.97 (0.034) | 18.59 (0.022) | 2.195 | 0.138 | 1.566 [0.861-2.848] |
| G C G C C G A C G A G G T | 14.27 (0.017) | 25.60 (0.031) | 3.076 | 0.079 | 0.559 [0.290-1.080] |
| G C G C T T A T G C G A T | 95.58 (0.117) | 102.81 (0.123) | 0.151 | 0.697 | 0.941 [0.694-1.277] |
| G C G T T G A C A C G A T | 98.94 (0.121) | 108.36 (0.130) | 0.295 | 0.587 | 0.920 [0.682-1.242] |
| others† | 236.23 (0.288) | 238.98 (28.6) | - | - | - |
For each haplotype, alleles were arranged in order of rs12638212-rs9842751-rs7635009- rs2278980-rs1463431-rs4855559-rs9288876-rs936266-rs7652606-rs2290600-rs1454197-rs12493483-rs10933946. OR, 95% CI: Odds Ratio, 95% Confidence Interval. N: number of haplotype in case and control group. x2: value tested by Pearson's Chi-squared test. ∗Adjusted for sex, age, BMI, and smoking history with logistic regression. †The lowest frequency threshold (LFT) < 0.03 was pooled in this part.