Chan 2016.
| Study characteristics | |||
| Patient sampling | Patient‐informant dyads were recruited in two phases. Phase I (screening): “participants were recruited if they were aged 60 and above, had provided informed consent, and had a suitable informant with frequent interactions for at least 10 hours.” Phase II (validation): “participants were recruited if they had completed phase 1, provided informed consent, and had no physical disabilities that affected their ability to perform the cognitive assessments.” Participants underwent additional evaluations. Most exclusions were due to patient choice; no other exclusion criteria were specified. |
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| Patient characteristics and setting | Patients at government‐subsidised primary healthcare settings aged over 60 years | ||
| Index tests | AD‐8 Chinese and Malay translations | ||
| Target condition and reference standard(s) | DSM‐IV criteria and CDR global scores used to determine presence of dementia and severity | ||
| Flow and timing | There probably is a gap between Phase I and Phase II, but the duration is not specified or explained. | ||
| Comparative | |||
| Notes | All patients who made it to Phase II were included, but more than 90% of the patients found eligible for Phase I were lost. | ||
| Methodological quality | |||
| Item | Authors' judgement | Risk of bias | Applicability concerns |
| DOMAIN 1: Patient Selection | |||
| Was a consecutive or random sample of patients enrolled? | Unclear | ||
| Was a case‐control design avoided? | Unclear | ||
| Did the study avoid inappropriate exclusions? | Unclear | ||
| Unclear | Low | ||
| DOMAIN 2: Index Test All tests | |||
| Were the index test results interpreted without knowledge of the results of the reference standard? | Yes | ||
| If a threshold was used, was it pre‐specified? | Unclear | ||
| Unclear | Low | ||
| DOMAIN 3: Reference Standard | |||
| Is the reference standards likely to correctly classify the target condition? | Yes | ||
| Were the reference standard results interpreted without knowledge of the results of the index tests? | Yes | ||
| Low | Low | ||
| DOMAIN 4: Flow and Timing | |||
| Was there an appropriate interval between index test and reference standard? | Unclear | ||
| Did all patients receive the same reference standard? | Unclear | ||
| Were all patients included in the analysis? | No | ||
| High | |||