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. 2019 Mar 4;2019(3):CD011121. doi: 10.1002/14651858.CD011121.pub2

Razavi 2014.

Study characteristics
Patient sampling Consecutive sample from memory clinic plus patients from a neurology clinic. Sample was 'enriched' with cognitively normal control patients.
33 patients with comorbid medical conditions that could potentially affect cognition but were not dementias were excluded.
Patient characteristics and setting Mixed population from various referral pathways
Index tests AD‐8
Target condition and reference standard(s) The study states that it uses "published criteria" but does not further operationalise
Flow and timing 33 patients with comorbid medical conditions that could potentially affect cognition but were not dementias were excluded. The timing of clinical and informant assessment is not clear.
Comparative  
Notes  
Methodological quality
Item Authors' judgement Risk of bias Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled? Yes    
Was a case‐control design avoided? Unclear    
Did the study avoid inappropriate exclusions? No    
    High High
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard? Yes    
If a threshold was used, was it pre‐specified? Yes    
    Low Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition? Unclear    
Were the reference standard results interpreted without knowledge of the results of the index tests? Yes    
    Unclear Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard? Unclear    
Did all patients receive the same reference standard? Yes    
Were all patients included in the analysis? No    
    High