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. 2018 Dec 7;4(1):164–169. doi: 10.1002/epi4.12287

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© 2018 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Temperature threshold for hyperthermia‐induced myoclonic seizures and generalized tonic‐clonic seizures (GTCS) in F1J.Scn1a ^+/− (F1J; n = 24) and F1N.Scn1a ^+/− (F1N; n = 26) mice. A, Cumulative myoclonic seizure incidence curve. The myoclonic seizure threshold was lower in F1N.Scn1a ^+/− (median = 40.2°C) compared to F1J.Scn1a ^+/− mice (median = 40.6°C) (P < 0.023, LogRank Mantel‐Cox). B, Cumulative GTCS incidence curve. GTCS incidence curves were not significantly different between F1N.Scn1a ^+/− and F1B.Scn1a ^+/− mice (P > 0.332, LogRank Mantel‐Cox). However, for mice that exhibited a GTCS at ≤42.5°C, average GTCS threshold temperature was significantly lower between F1N (41.8 ± 0.1°C) and F1J (42.2 ± 0.1°C) (P < 0.009, Mann Whitney U‐test)