Table 1.
GA/sex | Seizure onset (d) | Semiology (seizure description by author) | Seizure classification | Etiology | EEG |
---|---|---|---|---|---|
Pisano et al Epilepsia, 2015. N = 7/15 | |||||
(NA)/female | 3rd | Tonic asymmetric | Tonic | KCNQ2 encephalopathy | Burst‐suppressiona |
(NA)/female | 1st | Tonic asymmetric, apnea | Tonic | KCNQ2 encephalopathy | Burst‐suppressiona |
(NA)/male | 3rd | Tonic asymmetric | Tonic | KCNQ2 encephalopathy | Focal (temporal) |
(NA)/female | 1st | Clonic | Clonic | KCNQ2 encephalopathy | Multifocal |
(NA)/male | 2nd | Tonic and clonic | Sequential (tonic, clonic) | KCNQ2 encephalopathy | Multifocal |
(NA)/female | 3rd | Tonic asymmetric | Tonic | KCNQ2 encephalopathy | Multifocal |
(NA)/male | 2nd | Tonic asymmetric | Tonic | KCNQ2 encephalopathy | Multifocal |
Dereymaeker et al Eur J Pediatr Neurol, 2015. N = 1/1 | |||||
Term/female | 9th | Clonic movements | Clonic | Transient hypothyroidism/viral encephalitis by HPeV type 3 | Multifocal |
Cirillo et al Pediatrics, 2015. N = 2/2 | |||||
Term/female | 5th | Myoclonic‐tonic and tonic seizures (rhythmic movements of extremities, eye deviation, oxygen desaturation). | Sequential (myoclonic, tonic, autonomic) | ALDH7A1 heterozygous mutation (c.328C.T; p.R1103) | Multifocal sharp waves |
Term/female | 21st | Myoclonic jerks of arms and legs and tonic head deviation (tonic) | Sequential (myoclonic, tonic) | ALDH7A1—unknown | Bilateral continuous epileptiform discharges |
Machado et al Einstein (São Paulo), 2015. N = 2/11 | |||||
(NA)/(NA) | 9th | Multifocal clonic | Clonic | Left MCA ischemic stroke | Burst‐suppressiona |
(NA)/(NA) | 1st | Focal clonic | Clonic | Left MCA ischemic stroke | Focal (left temporal) |
Raimondi et al BMJ Case Report, 2015. N = 1/1 | |||||
Preterm/female | 1st | Eyelid blinking, hypersalivation with orobuccal rhythmic movements | Sequential (automatisms, autonomic) | Pyridoxal 5‐phosphate deficiency, PNPO mutation | Burst suppression (background pattern) |
Nascimento et al Pediatr Neurol, 2015. N = 1/1 | |||||
Preterm/male | 20th | Crying, conjugate eye deviation to the right, myoclonus of the left eyelid, followed by chewing episodes with sialorrhea | Sequential (tonic, myoclonic, automatisms) | β‐oxidation defect from a D‐bifunctional protein deficiency | Multifocal |
Fukasawa et al Am J Med Gent A, 2015. N = 2/7 | |||||
Preterm/male | 28th | Apnea and tachycardia, sometimes followed by tonic posturing | Sequential (autonomic, tonic) | Trisomy 18 | Rhythmic spikes and slow waves of 2‐3 Hz from the right temporal‐occipital region |
Term/female | 2nd | Apnea | Autonomic | Trisomy 18 | Rhythmic spikes and slow waves of 1‐2 Hz from the right temporal‐rolandic‐occipital region |
Guerin et al J Child Neurol, 2015. N = 1/1 | |||||
Preterm/female | 1st | Fragmentary and generalized myoclonic jerks | Myoclonic | Pyridox(am)ine‐5‐phosphate oxidase deficiency | Burst‐suppression (background pattern) |
Spagnoli et al J Child Neurol, 2015. N = 2/2 | |||||
Preterm/male | 5th | Multifocal clonic | Clonic | IVH grade III with posthemorrhagic hydrocephalus | Multifocal discharges, alpha‐beta range, left centrotemporal or posterior emphasis, less frequently with a right temporal onset |
Preterm/female | 30th | Clonic events | Clonic | IVH with posthemorrhagic hydrocephalus | Low‐voltage alpha‐beta activity over the anterior regions, mainly expressed over the right |
Paddock et al J Neonatal Perinatal Med, 2014. N = 1/1 | |||||
Term/female | 1st | Clonic (right hand and leg) | Clonic | Left MCA ischemic stroke | Focal spikes left hemisphere (aEEG) |
Saitsu et al J Hum Genet, 2014. N = 2/2 (siblings) | |||||
Term/female | 7th | Focal clonic followed by generalized tonic‐clonic | Sequential (clonic, tonic) | Ohtahara (BRAT1 mutation) | Burst‐suppression (background pattern) |
Term/female | 1st | Generalized myoclonic seizures and partial clonic, after tonic and apnea | Sequential (myoclonic, clonic, tonic, autonomic) | Ohtahara | Burst‐suppression (background pattern) |
Ito et al J Perinatol, 2014. N = 1/1 | |||||
Term/female | 1st | Deviation of eyeballs, nystagmus, twitching of the eyelids, tonic or clonic activities of the limbs or apnea | Sequential (tonic, autonomic) | Holoprosencephaly | Low‐voltage fast rhythms followed by slow waves of increasing amplitude C3‐C4 (aEEG) |
Allen et al Epilepsia, 2014. N = 3/3 | |||||
Term/female | 4th | Mainly clonic, but also tonic, minor cyanosis | Sequential (clonic, tonic, autonomic) | BFNS‐KCNQ2c.419_430dup | Bilateral independent high‐amplitude sharp waves of 1 Hz, normal background |
Term/female | 6th | Clonic | Clonic |
BFNS‐KCNQ3 c.989G>A |
Excessive sharp waves, normal background |
Term/male | 1st | Tonic arm and trunk with cyanosis, grunting and duskiness followed by apnea and hypoxia | Sequential (tonic, autonomic) | KCNQ2‐.881C>T encephalopathy | Ictal pattern: focal recruiting rhythm right parietal region Interictal: multifocal discharges, followed by background attenuation |
Low et al PLoS ONE, 2014. N = 9/9 | |||||
Term/male | 1st | Clonic right arm | Clonic | Left MCA ischemic stroke | Focal spikes, left central |
Term/male | 2nd | Dusky episodes | Autonomic | Left MCA ischemic stroke | Focal spikes. left central |
Term/male | 1st | Clonic left side | Clonic | Right MCA ischemic stroke | Focal spikes, right central |
Term/female | 1st | Clonic right side | Clonic | Right/left MCA ischemic stroke | Focal spikes, polyspikes left central |
Term/female | 2nd | Clonic left leg | Clonic | Right MCA ischemic stroke | Focal spikes, polyspikes right central |
Term/female | 2nd | Clonic right side | Clonic | Left MCA ischemic stroke | Focal spikes, left central |
Term/male | 1st | Clonic right arm | Clonic | Left MCA ischemic stroke | Focal spikes, left central |
Term/male | 1st | Clonic right arm | Clonic | Right/left MCA ischemic stroke | Focal spikes, polyspikes left central |
Term/male | 2nd | Clonic left leg | Clonic | Right MCA ischemic stroke | Focal spikes, polyspikes right central |
Pariani et al Pediatr Infect Dis J, 2014. N = 1/2 | |||||
Term/female | 9th | Myoclonic seizures, apnea and staring | Sequential (myoclonic, autonomic, behavioral arrest) | Parechovirus 3 encephalitis | Paroxysmal activity in the left and right hemisphere |
Zerem et al Eur J Paediatr Neurol, 2014. N = 2/2 | |||||
Term/male | 1st | General tonic extension, cry and usually desaturation | Sequential (tonic, autonomic) | SCN2A mutation (Ohtahara) | Burst‐suppression (background pattern) |
Term/male | 1st | Tonic seizure, eye deviation, bradycardia | Sequential (tonic, autonomic) | SCN2A mutation (Ohtahara) | Ictal: focal discharges right frontal region Interictal: Burst‐suppression background |
Ansary et al Singapore Med J, 2014. N = 1/1 | |||||
Preterm/female | 2nd | Multifocal myoclonic (both arms and legs) | Myoclonic | Venlafaxine withdrawal | Focal sharp waves (aEEG) |
Kharoshankaya et al Dev Med Child Neurol, 2014. N = 1/1 | |||||
Term/male | 1st | Clonic (right arm and leg) associated with mouthing and cyanosis | Sequential (clonic, automatisms) | Thalamic infarction | Low voltage (<10 μv) focal left‐sided biphasic spike‐wave discharges |
Fong et al Pediatr Infect Dis J, 2014. N = 1/1 | |||||
Term/female | 13th | Focal clonic arm | Clonic | Herpes simplex virus type 1 | Focal epileptiform discharges over the midline‐vertex and right frontal‐midline regions |
Numis et al Neurology, 2014, N = 3/3 | |||||
Preterm/NA | 4th day | Tonic head, conjugate eye, and mouth deviation, unilateral tonic abduction of the limbs, apnea, and desaturation | Sequential (tonic, autonomic) | KCNQ2 epileptic encephalopathy | Low‐voltage fast activity followed by recruiting spikes or theta rhythms arising mainly from the central regions of either hemisphere, followed by focal spike‐wave complexes and prolonged focal or diffuse postictal suppression |
Term/NA | 1st day | Tonic head, conjugate eye, and mouth deviation, unilateral tonic abduction of the limbs, apnea, and desaturation | Sequential (tonic, autonomic) | KCNQ2 epileptic encephalopathy | Focal low‐voltage fast activity followed by rhythmic theta rhythm from the fronto central region of both hemispheres, alternatively followed by diffuse marked postictal suppression lasting up to 8 minutes |
Term/NA | 1st day | Tonic head, conjugate eye, and mouth deviation, unilateral tonic abduction of the limbs, apnea, and desaturation | Sequential (tonic, autonomic) | KCNQ2 epileptic encephalopathy | Low‐voltage fast activity followed by focal theta rhythms involving the right or left hemisphere |
Porri et al Neuropediatrics, 2014. N = 1/1 | |||||
Preterm/male | 1st | Erratic myoclonic jerks involving all four extremities | Myoclonic | Pyridoxal‐5′‐Phosphate Oxidase Deficiency | Burst‐suppression (ictal) |
Khajeh et al J Child Neurol, 2014. N = 1/1 | |||||
Term/female | 1st | Apnea | Autonomic | Polymicrogyria left temporal and frontal lobes | Left temporal 9‐10 Hz activity, evolving into 2‐ to 3‐Hz sharp and slow‐wave activity |
Weckhuysen et al Neurology, 2013. N = 11/11 | |||||
(NA)/female | 1st | Tonic asymmetrical with apnea, bradycardia and desaturation, continuous complex movements of legs | Sequential (tonic, autonomic, clonic or automatisms) | KCNQ2 mutation | Burst‐suppressiona |
(NA)/female | 2nd | Apnea, erratic myoclonic and tonic contraction | Sequential (autonomic, myoclonic, tonic) | KCNQ2 mutation | Burst‐suppressiona |
(NA)/male | 2nd | Tonic generalized | Tonic | KCNQ2 mutation | Burst‐suppressiona |
(NA)/male | 1st | Tonic generalized with apnea, grimacing, followed by mastication and sialorrhea | Sequential (tonic, autonomic) | KCNQ2 mutation | Burst‐suppressiona |
(NA)/male | 2nd | Tonic with pursing of lips, clenching of eyes and cyanosis, sometimes eye deviation and flickering of eyeballs | Sequential (tonic, automatism, autonomic) | KCNQ2 mutation | Burst‐suppressiona |
(NA)/female | 2nd | Tonic asymmetrical with sucking movements of mouth | Sequential (tonic, automatism) | KCNQ2 mutation | Burst‐suppressiona |
(NA)/female | 1st | Tonic asymmetrical with apnea | Tonic | KCNQ2 mutation | Multifocal |
(NA)/male | 1st | Tonic asymmetrical with apnea | Tonic | KCNQ2 mutation | Focal evolving to multifocal |
(NA)/female | 3rd | Tonic asymmetrical followed by hemiclonic | Sequential (tonic, clonic) | KCNQ2 mutation | Multifocal |
(NA)/female | 1st | Tonic generalized | Tonic | KCNQ2 mutation | Focal spike waves |
(NA)/female | 2nd | Tonic asymmetrical and apnea | Tonic | KCNQ2 mutation | Bilateral spikes |
Borkenhagen et al Pediatr Neurol, 2013. N = 1/1 OK | |||||
Term/female | 5th | Clonic right foot, with subsequent multifocal clonic (arms and legs independently) | Clonic | Hypocalcemia | High‐voltage, rhythmic spike‐wave discharges, left vertex region with spread into the left posterior temporal, left parietal, and right parietal regions. |
Serino et al Epileptic Disord, 2013. N = 1/1 | |||||
Term/male | 3rd day | Focal, tonic seizures with head deviation, asynchronous and asymmetrical clonic jerks, eyelid myoclonias, and polypnea | Sequential (tonic, clonic) | KCNQ2 epileptic encephalopathy | Focal, low‐voltage, fast activity, followed by recruiting theta rhythms and bilateral, focal, spike‐wave complexes, alternatively localized to one hemisphere and subsequently diffusing to the other |
Mihl et al Orphanet J Rare Dis, 2013. N = 16/16 | |||||
Term/(NA) | 1st | Clonic and tonic | Sequential (clonic, tonic) | KCNQ2 mutations | Burst‐suppressiona |
Preterm/(NA) | 15th | Myoclonic | Myoclonic | KCNQ2 mutations | Periods of flatnessa |
Term/(NA) | 3rd | Tonic, pallor 2 | Tonic | KCNQ2 mutations | Burst‐suppressiona |
Term/(NA) | 2nd | Tonic and hypotonic. Epileptic spasms | Sequential (tonic, epileptic spasms) | KCNQ2 mutations | Burst‐suppressiona |
Term/(NA) | 2nd | Tonic and tonic‐clonic, cyanosis | Sequential (tonic, clonic, autonomic) | KCNQ2 mutations | Generalized spikes predominating on the left hemisphere followed by suppression burst. a |
Term/(NA) | 2nd | Left and right clonic jerks, facial cyanosis. | Clonic | KCNQ2 mutations | Burst‐suppressiona |
Term/(NA) | 1st | Isolated cyanosis, than recurrent hypertonic posture | Sequential (autonomic, tonic) | KCNQ2 mutations | Burst‐suppressiona |
(NA)/(NA) | 1st | Tonic asymmetric. | Tonic | KCNQ2 mutations | Bursts of multifocal spikes . |
Term/(NA) | 3rd | Tonic | Tonic | KCNQ2 mutations | Burst‐suppressiona |
Term/(NA) | 1st | Tonic and/or clonic | Sequential (tonic, clonic) | KCNQ2 mutations | Burst of asynchronous spikes and sharp waves. Periods of discontinuity with flatness no typical burst suppression |
Term/(NA) | 1st | Tonic and cyanosis | Tonic | KCNQ2 mutations | Left or right spikes on a moderately abnormal background |
Term/(NA) | 4th | Asymmetric tonic extension of one limb. Bilateral clonic seizures. Apnea. | Sequential (tonic, clonic, autonomic) | KCNQ2 mutations | Burst‐suppressiona |
Term/(NA) | 4th | Clonic hemi corporeal, left or right | Clonic | KCNQ2 mutations | Prolonged periods of flatness. Discontinuous.a |
Term/(NA) | 1st | Tonic | Tonic | KCNQ2 mutations | Multifocal slow waves, left frontal and right occipital spikes. Asymmetrical suppression‐burst |
Preterm/(NA) | 8th | Myoclonic | Myoclonic | KCNQ2 mutations | Burst‐suppressiona |
Term/(NA) | 2nd | Bilateral tonic clonic and right clonic | Sequential (tonic, clonic) | KCNQ2 mutations | Slow waves with asynchronous bilateral spikes and intermittent flattening |
Tanriverdi et al Brain Dev, 2013. N = 1/1 | |||||
Term/female | 20th day | Focal seizures followed by generalization | Sequential (no specific description) | Sturge‐Weber | Isolated sharp spike‐wave discharges at parietal right hemisphere and at the frontotemporal areas of left hemisphere |
Kato et al Epilepsia, 2013. N = 12/12 | |||||
(NA)/female | 1st | Tonic, eye deviation | Tonic | KCNQ2 mutation | Burst‐suppression, asymmetric a |
(NA)/male | 3rd | Tonic | Tonic | KCNQ2 mutation | Multifocal sharp waves |
(NA)/male | 5th | Left sided tonic | Tonic | KCNQ2 mutation | Burst‐suppression, brief suppression a |
(NA)female | 2nd | Tonic | Tonic | KCNQ2 mutation | Burst‐suppression, asymmetric a |
(NA)/male | 1st | Tonic | Tonic | KCNQ2 mutation | Burst‐suppression, brief suppression a |
(NA)/male | 30th | Asymmetric tonic | Tonic | KCNQ2 mutation | Burst‐suppressiona |
(NA)/male | 14th | Tonic | Tonic | KCNQ2 mutation | Burst‐suppression, asymmetric a |
(NA)/male | 2nd | Tonic | Tonic | KCNQ2 mutation | Burst‐suppression, brief suppression a |
(NA)/female | 2nd | Tonic | Tonic | KCNQ2 mutation | Burst‐suppression, like hypsarrhythmia a |
(NA)/female | 14th | Generalized tonic | Tonic | KCNQ2 mutation | Burst‐suppression, brief suppression a |
(NA)/male | 1st | Postural tonic | Tonic | KCNQ2 mutation | Burst‐suppressiona |
(NA)/female | 3rd | Tonic, facial clonic | Sequential (tonic, clonic) | KCNQ2 mutation | Burst‐suppression, asymmetric a |
Simoneti et al Epilepsia, 2012. N = 2/2 | |||||
Term/female | 1st | Unusual cry, wide opening of the eyes, flushing, and bulbar and head deviation to the right | Sequential (autonomic, tonic) | Duplication of the sodium channel gene cluster on 2q24 5.1 | Right centrotemporal, also bicentral, slow, repetitive spike wave activity, followed by background slowing. |
Term/female | 3rd | Focal tonic, multifocal clonic seizures, starts with central cyanosis and head deviation | Sequential (autonomic, tonic, clonic) | Duplication of the sodium channel gene cluster on 2q24 | Generalized suppression of the background activity, followed by sharp and slow waves, secondarily generalizing. |
Riesgo et al Neuropediatrics, 2012. N = 3/3 | |||||
Preterm/male | 10th | Apnea and desaturation | Autonomic | Undetermined | Focal rhythmic activity on the left temporal region. |
Preterm/female | 22nd | Apnea | Autonomic | Periventricular leukomalacia | Multifocal paroxysms occurred mainly in the right temporal region |
Preterm/female | 2nd | Apnea, clonic upper limbs | Sequential (autonomic, clonic) | Undetermined 7.0 | Multifocal paroxysms and EEG seizures in both hemispheres mainly at left temporal region |
Cusmai et al Eur J Pediatr Neurol, 2012. N = 3/3 | |||||
Term/female | 2nd | Myoclonic seizures and epileptic tonic spasms. | Myoclonic | Nonketotic hyperglycinemia | Burst‐suppression (background pattern) |
Term/male | 2nd | Myoclonic jerks and infantile spasms | Myoclonic | Nonketotic hyperglycinemia | Burst‐suppression (background pattern) |
Term/male | 1st | Myoclonic jerks and tonic spasms | Myoclonic | Nonketotic hyperglycinemia | Burst‐suppression (background pattern) |
Vatta et al J Child Neurol, 2012. N = 1/1 | |||||
Term/male | 14th day | Opening of the eyes followed by body stiffening and breathing difficulties, clonic right arm | Sequential (tonic, autonomic, clonic) | STXBP1 mutation 5.3 | Focal discharges, left central region, alpha/theta range |
Weckhuysen et al Ann Neurol, 2012. N = 6/8 | |||||
(NA)/female | 2nd day | Apnea, generalized stiffening with facial suffusion, followed by pallor and cyanosis | Sequential (autonomic, tonic) | KCNQ2 epileptic encephalopathy | Continuous multifocal and bilaterally synchronous epileptiform activity. |
(NA)/female | 3rd day | Stiffening, head and eye deviation and tonic posturing | Sequential (autonomic, tonic) | KCNQ2 epileptic encephalopathy | Centroparietal ictal rhythm evolving to high‐voltage slowing (right‐sided in 2 seizures and left‐sided in 1) |
(NA)/male | 2nd day | Generalized tonic with clonic components, lip smacking, back arching, apnea | Sequential (tonic, clonic, automatism, autonomic) | KCNQ2 epileptic encephalopathy | Multifocal epileptic activity most frequently seen in left temporal and right frontal regions. |
(NA)/female | 3rd day | Tonic seizure, followed by myoclonic jerks and nystagmus | Sequential (tonic, myoclonic) | KCNQ2 epileptic encephalopathy | Burst‐suppressiona |
(NA)/male | 3rd day | Tonic extension with clonic movements left hemicorpus and eyelid myoclonia | Sequential (tonic, myoclonic) | KCNQ2 epileptic encephalopathy | Burst‐suppressiona |
(NA)/female | 2nd day | Tonic extension, high pitch cry, cyanosis and bradypnea, eventually with myoclonias (arms) | Sequential (tonic, myoclonic, autonomic) | KCNQ2 epileptic encephalopathy | Burst‐suppressiona |
Blumkin et al Eur J Pediatr Neurol, 2012. N = 1/1 | |||||
Term/male | 2nd | Multifocal clonic | Clonic | KCNQ2 mutation | Generalized spike and wave (2‐2.5 Hz) with phase reversal in the rolandic area bilaterally. |
Castro‐ Conde et al Pediatrics, 2012. N = 2/2 | |||||
Term/male | 1st day | Eye opening, tachycardia, tonic eye deviation to the left, slow blinking, mouth movements, right arm abduction with clenched fist and eye deviation to the right followed by apnea | Sequential (autonomic, automatisms, tonic) | Ischemic stroke | Rhythmic sharp waves left temporal followed by generalized background suppression |
Term/female | 2nd day | Apnea | Autonomic | Unknown | Focal occipital discharges |
Hirata et al Neuropediatrics, 2011. N = 1/1 | |||||
Term/female | 16th | Clonic seizures right arm and leg | Clonic | Coxsackie B2 Meningoencephalitis | Multifocal spikes |
Milh et al Epilepsia, 2011. N = 4/5 | |||||
(NA)/(NA) | 1st | Clonic asynchronous | Clonic | STXBP1 (MUNC18‐1) mutations | Burst‐suppressiona |
(NA)/(NA) | 1st | Clonic asynchronous | Clonic | STXBP1 (MUNC18‐1) mutations | Burst‐suppressiona |
(NA)/(NA) | 3rd | Epileptic spasms | Epileptic spasms | STXBP1 (MUNC18‐1) mutations | Burst‐suppressiona |
(NA)/(NA) | 1st | Epileptic spasms | Epileptic spasms | STXBP1 (MUNC18‐1) mutations | Burst‐suppressiona |
Walsh et al Dev Med Child Neurol, 2011. N = 1/1 | |||||
Term/female | 1st to 2nd day | Lip smacking and tonic‐clonic | Sequential (automatisms, tonic, clonic) | Ischemic stroke | Bursts sharp waves left hemisphere |
Millet et al Eur J Pediatr Neurol, 2011. N = 1/1 | |||||
Term/male | 1st | Clonic | Clonic | Pyridoxine‐dependent epilepsy with mutation in the ALDH7A1 gene | Rhythmic spikes that predominated in the right or left hemisphere, in the temporal region. Burst‐suppression background |
Heron et al Epilepsia, 2010. N = 1/1 ok | |||||
Term/male | 4th day | Myoclonic | Myoclonic | QT prolongation mutation in SCN5A c.4868G>A (p.R1623Q) | Bilateral rhythmic epileptic discharges predominantly posterior (O1 and O2) with a right‐sided emphasis. |
Gibson & Bharti. Tenn Med, 2010. N = 2/2 ok | |||||
Term/female | 1st | Focal clonic left leg | Clonic | Left MCA ischemic stroke | Rhythmic discharges left temporal spreading to frontal/central regions |
Term/female | 1st | Focal tonic clonic, smacking lips, tongue deviation | Sequential (tonic, clonic, automatisms) | Right MCA ischemic stroke | Multifocal sharp waves |
Schmitt et al Dev Med Child Neurol, 2010. N = 1/5 ok | |||||
Term/female | 7th | Focal clonic | Clonic | Pyridoxine‐dependent epilepsy | Central spikes |
Okumura et al Brain Dev, 2008. N = 3/9 ok | |||||
Preterm/male | 25th day | Autonomic 7 | Autonomic | Severe hypotension hyperkalemia | Right temporal rhythmic slow voltage spikes |
Preterm/female | 1st day | Apnea | Autonomic | Neonatal encephalopathy | Rhythmic spikes, right temporal |
Preterm/female | 1st day | Apnea | Autonomic | Subarachnoid hemorrhage | Rhythmic spikes, left temporal |
Nunes et al Arq Neuropsiquiatr (São Paulo), 2008. N = 6/101 | |||||
Term/female | 4th day | Clonic left arm, after left leg, chewing movements | Sequential (clonic, automatisms) | Benign familial neonatal seizures | Rhythmic discharges theta range right central and temporal with propagation to left central |
Term/male | 1st day | Multifocal clonic | Clonic | Hypoxic‐ischemic encephalopathy | Rhythmic spikes, right temporal and rolandic |
Term/male | 2nd day | Clonic left arm and face | Clonic | Abstinence | Rhythmic discharges, right occipital |
Term/female | 2nd day | Clonic focal left arm | Clonic | Right MCA ischemic infarct | Rhythmic spike and slow wave right rolandic, with propagation to right frontal |
Term/female | 2nd day | Apnea | Autonomic | Hypoxic‐ischemic encephalopathy | Rhythmic discharges, left occipital |
Term/female | 1st day | Clonic focal right arm, blinking right eye | Clonic | Left MCA ischemic infarct | Rhythmic discharges, delta range, left rolandic |
Kubota et al Brain Dev, 2008. N = 1/1ok | |||||
Term/female | 2nd day | Clonic left side, with open eyes deviating to the left, and automatism around the mouth | Sequential (clonic, tonic, automatism) | Hypoxic‐ischemic encephalopathy | Semi‐rhythmic, repetitive spikes predominantly in the right central region |
Shah et al N Engl J Med, 2008. N = 1/1 | |||||
Term/female | 1st | Apnea | Autonomic | Left MCA ischemic stroke | Sharp waves left temporal |
Vecchi et al Epileptic Dis, 2007. N = 1/1 | |||||
Preterm/male | 7th | Behavioral arrest, staring, apnea, deviation of the head and the eyes to the right, dystonic posture of the left hand and bilateral, automatic hand movements | Sequential (behavior arrest, autonomic, tonic) | Undetermined | Rapid rhythms of low voltage in the right temporal region followed by theta rhythmic activity and rhythmical sharp and wave complexes |
Gorman & Soul. Pediatr Neurol, 2007. N = 1/1 | |||||
Term/male | 3 rd | Tonic‐clonic | Sequential (tonic, clonic) | Hypocalcemia | Left central and vertex sharp waves that spread to right side |
Sirsi et al Pediatr Neurol, 2007.N = 3/3 | |||||
Term/male | 1st | Apnea, conjugate eye deviation to the right, focal clonic (right‐arm) | Sequential (autonomic, tonic, clonic) | Hemorrhage (left temporal lobe) | Left temporal sharp rhythmic delta activity, evolving into alpha with admixed theta sharp and slow‐wave |
Term/male | 1st | Apnea | Autonomic | Intraparenchymal hemorrhage (right temporal) and subdural (right tentorium) hematoma | Focal activity (right hemisphere) |
Term/male | 1st day | Apnea | Autonomic | Right temporal hemorrhagic infarct | Right temporal rhythmic spike and wave activity |
Lin et al Arq Neuropsiquiatr (São Paulo), 2007. N = 1/1 | |||||
Term/female | 1st | Focal myoclonic left arm and leg) tonic eye and head deviation to the right, eyelid blinking and oromandibular movements | Sequential (myoclonic, tonic, autonomic) | Pyridoxine‐dependent epilepsy | High‐voltage spike and polyspike‐wave complexes lateralized to the right cerebral hemisphere |
Hmaimess et al Pediatr Neurol, 2007. N = 1/1 | |||||
Term/male | 1st | Lateral deviation of the head and eyes, fixed sight, clonic jerks on one side of the body followed by clonic jerks of the other side | Sequential (tonic, clonic) | Malignant migrating partial seizures (etiology unknown) | Low‐voltage fast right central and occipital activity (9‐10 Hz), anterior ipsilateral flattening, followed by increased amplitude and slowing to theta and delta rhythmic activity left side |
Spinosa et al Arq Neuropsiquiatr (São Paulo), 2006. N = 1/1 | |||||
Term/male | 1st | Focal clonic (right hemiface and arm) | Clonic | X‐linked lissencephaly with ambiguous genitalia (XLAG) | Right midtemporal, central and occipital discharges |
Cherian et al Clin EEG Neurosci, 2006. N = 1/1 | |||||
Term/(NA) | (NA) | Nystagmoid movements | Automatism | Hypoxic‐ischemic encephalopathy | Focal bilateral occipital discharges |
Schmitt et al Epileptic Res, 2005. N = 6/6 | |||||
Term/(NA) | 1st day | Tonic followed by asymmetric clonic | Sequential (tonic, clonic) | Pyridoxine‐ dependent seizures | Bilateral synchronous spike‐wave discharges followed by suppression |
Term/(NA) | 1st day | Multifocal myoclonic jerks, intermittent tonic posturing or spasms, eye deviations and abnormal oral and mimic movements | Sequential (myoclonic, tonic, epileptic spasms, automatisms) | Pyridoxine‐ dependent seizures | Voltage suppression in EEG followed by bilateral synchronous spike‐wave discharges |
Term/female | 1st day | Tonic clonic‐myoclonic seizures | Sequential (tonic, clonic, myoclonic) | Undetermined | Rhythmic and sharp activity alternated from both hemispheres |
Term/male | 1st day | Tonic‐clonic | Sequential (tonic, clonic) | KCNQ2 | Voltage suppression, bilateral rhythmic alpha discharges |
Term/female | 1st day | Slow dystonic movements followed by focal clonic on right arm and leg | Sequential (tonic, clonic) | Undetermined | Voltage suppression rhythmic and sharp left hemisphere |
Term/male | 8th day | Tonic clonic | Sequential (tonic, clonic) | Undetermined | Multifocal |
Al‐Futaisi et al Clin Neurophysiol, 2005. N = 1/1 | |||||
Term/female | 5 days | Tonic spasms | Epileptic spasms | EIEE (etiology unknown) | Burst‐suppression (ictal) |
Schulzke et al J Perinatal Med, 2005. N = 6/9 | |||||
Preterm/male | 1st | Focal clonic | Clonic | Left MCA ischemic stroke | Focal left discharges |
Term/male | 1st | Apnea plus tonic and clonic | Sequential (autonomic, tonic, clonic) | Hemorrhage (left parietooccipital region) | Focal left discharges |
Term/female | 1st | Apnea plus tonic and clonic | Sequential (autonomic, tonic, clonic) | Left MCA ischemic stroke | PLEDS left |
Term/female | 2nd | Focal clonic | Clonic | Left MCA ischemic stroke | Focal left discharges |
Term/male | 3rd | Focal clonic | Clonic | Left MCA ischemic stroke | Focal left discharges and sharp/slow waves right |
Term/female | 2nd | Focal clonic | Clonic | Left MCA ischemic stroke | Focal left discharges |
Tramonte & Goodkin. J Perinatol, 2004. N = 1/1 | |||||
Term/male | 1st | Apnea | Autonomic | Intraparenchymal hemorrhage (right temporal) | Sharply contoured alpha activity evolving into periodic sharp and slow wave activity followed by rhythmic delta activity, right centrotemporal |
AED, antiepileptic drug; EIEE, early infantile epileptic encephalopathy; GA, gestational age, seizure onset expressed in days of life; IVH, intraventricular hemorrhage; LMCA, left middle cerebral artery; N, number of patients included/number of patients available in the study; PLEDs, pseudoperiodic epileptiform discharges; RMCA, right middle cerebral artery; (NA), not available. In this table we have maintained the description of seizure semiology and EEG findings as it is cited in the original article.
Indicates when burst‐suppression was not clearly defined as ictal or interictal pattern/background abnormality.