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. 2019 Feb 18;2019:9291683. doi: 10.1155/2019/9291683

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Copyright © 2019 Wenjing Shang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Downregulation of Trx-1 by lentiviral vector-mediated RNAi inhibits gastric cancer cell growth, clone formation, invasion and migration. (a) Decreased Trx-1 mRNA level in BGC-823 cells transduced with lenti-shTrx-1 revealed by quantitative RT-PCR. (b) Decreased Trx-1 protein level in BGC-823 cell transduced with lenti-shTrx-1 revealed by Western blotting. (c) Downregulation of Trx-1 inhibited BGC-823 cell growth as revealed by CCK-8 assay. (d) Downregulation of Trx-1 inhibited BGC-823 cell plate colony formation. (e) Downregulation of Trx-1 inhibited BGC-823 cell migration and invasion. Representative images from triplicate experiments are shown. Magnification, ×200. The quantitation of migrated and invaded cells is shown in the bottom panel. ^∗ P < 0.05, ^∗∗ P < 0.01, ^∗∗∗ P < 0.001.