Table 2. XI(50), IC50, and Standard Error Values for the Inhibition of cPLA2 by Pyrrophenone, iPLA2 by OTFP, and sPLA2 by Ly315920, Respectively, Calculated by Performing Three Independent Dose–Response Inhibition Experiments on Each Inhibitor.
pyrrophenone |
OTFP |
LY315920 |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
positive |
negative |
positive |
negative |
positive |
negative |
|||||||
XI(50) | IC50 (μM) | XI(50) | IC50 (μM) | XI(50) | IC50 (μM) | XI(50) | IC50 (μM) | XI(50) | IC50 (μM) | XI(50) | IC50 (μM) | |
0.0027 | 1.83 | 0.0027 | 1.88 | 0.00008 | 0.054 | 0.00007 | 0.049 | 0.00015 | 0.104 | 0.00019 | 0.131 | |
0.0019 | 1.32 | 0.0020 | 1.38 | 0.00008 | 0.058 | 0.00009 | 0.060 | 0.00018 | 0.124 | 0.00018 | 0.127 | |
0.0023 | 1.61 | 0.0021 | 1.47 | 0.00007 | 0.051 | 0.00005 | 0.034 | 0.00017 | 0.116 | 0.00020 | 0.136 | |
average | 0.0023 | 1.59 | 0.0023 | 1.58 | 0.00008 | 0.055 | 0.00007 | 0.048 | 0.00017 | 0.114 | 0.00019 | 0.131 |
STDEV | 0.0004 | 0.26 | 0.0004 | 0.27 | 0.000005 | 0.004 | 0.00002 | 0.013 | 0.00001 | 0.010 | 0.00001 | 0.004 |