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. 2019 Jan 7;62(4):1999–2007. doi: 10.1021/acs.jmedchem.8b01568

Table 2. XI(50), IC50, and Standard Error Values for the Inhibition of cPLA2 by Pyrrophenone, iPLA2 by OTFP, and sPLA2 by Ly315920, Respectively, Calculated by Performing Three Independent Dose–Response Inhibition Experiments on Each Inhibitor.

  pyrrophenone
OTFP
LY315920
  positive
negative
positive
negative
positive
negative
  XI(50) IC50 (μM) XI(50) IC50 (μM) XI(50) IC50 (μM) XI(50) IC50 (μM) XI(50) IC50 (μM) XI(50) IC50 (μM)
  0.0027 1.83 0.0027 1.88 0.00008 0.054 0.00007 0.049 0.00015 0.104 0.00019 0.131
  0.0019 1.32 0.0020 1.38 0.00008 0.058 0.00009 0.060 0.00018 0.124 0.00018 0.127
  0.0023 1.61 0.0021 1.47 0.00007 0.051 0.00005 0.034 0.00017 0.116 0.00020 0.136
average 0.0023 1.59 0.0023 1.58 0.00008 0.055 0.00007 0.048 0.00017 0.114 0.00019 0.131
STDEV 0.0004 0.26 0.0004 0.27 0.000005 0.004 0.00002 0.013 0.00001 0.010 0.00001 0.004