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. 2019 Jan 29;10(9):930–941. doi: 10.18632/oncotarget.26584

Figure 2. Recurrent hotspot SF3B1 R625 mutations and co-occurrence mutation events in mucosal melanoma.

Figure 2

(A) Lollipop plots showing amino acid changes (p.Arg625His/Leu) at codon 625 on SF3B1 protein structure in the present mucosal melanoma study, Australian Melanoma Genome Project and The Cancer Genome Atlas (SKCM-TCGA). The y-axis shows the number of mutations and the x-axis represent the amino acid residues of SF3B1 protein. Representative images of two cases (H & E x 4–upper panel, H & E x 20–lower panel) of mucosal melanoma with SF3B1 mutation obtained from vulva (B) and (C) rectal sites.