Table 2. Association of SF3B1 mutations with clinicopathological features.
| Characteristics | SF3B1 mutations identified (n = 6) N (%)a |
Non-SF3B1 mutations identified (n = 21)a N (%)a |
P-value |
|---|---|---|---|
| Age (median, IQR) | 52.5 years, 46.5–71.5 years | 64 years, 54.5–79 years | 0.309 |
| Gender Female Male |
4 (67%) 2 (33%) |
18 (86%) 3 (14%) |
0.303 |
| Site Vulva/vagina Other sites (total) Anorectal Nasopharyngeal Conjunctiva Palate |
3 (50%) 3 (50%) in total 2 (33%) 0 (0%) 1 (17%) 0 (0%) |
12 (57%) 9 (43%) in total 3 (14%) 5 (24%) 0 (0%) 1 (5%) |
>0.999 |
| T classification 0–2 3–4 Data unavailable |
2 (33%) 4 (67%) 0 (0%) |
5 (24%) 13 (62%) 3 (14%) |
>0.999 |
| N classification N0 N+ Data unavailable |
5 (83%) 0 (0%) 1 (17%) |
12 (57%) 7 (33%) 2 (10%) |
0.272 |
| Mitotic rate (number of mitoses/mm2) < 10 ≥ 10 Data unavailable |
1 (17%) 4 (67%) 1 (17%) |
6 (29%) 10 (48%) 5 (24%) |
0.624 |
| Ulceration Absent Present Data unavailable |
0 (0%) 6 (100%) 0 (0%) |
6 (29%) 10 (48%) 5 (24%) |
0.133 |
| Tumor thickness (mm) <1 1–4 ≥ 4 Data unavailable |
0 (0%) 3 (50%) 3 (50%) 0 (0%) |
1 (5%) 6 (29%) 10 (48%) 4 (19%) |
0.655b |
| Cell morphology Epithelioid Mixed Spindle Data unavailable |
3 (50%) 2 (33%) 1 (17%) 0 (0%) |
13 (62%) 1 (5%) 4 (19%) 3 (14%) |
0.362c |
a Unless otherwise indicated.
b Tissue with <1 mm is excluded from statistical testing.
c Statistical testing was performed by comparing epithelioid and other cell morphology (mixed and spindle).