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. Author manuscript; available in PMC: 2019 Mar 4.
Published in final edited form as: Diabetes Obes Metab. 2012 Oct;14(Suppl 3):1–11. doi: 10.1111/j.1463-1326.2012.01645.x

Figure 8.

Figure 8.

SYT8 gene expression is regulated by CTCF and is important for insulin secretion in human pancreatic islets. (A) Effect of siRNA-induced downregulation of CTCF expression on SYT8 expression in islets from two donors. INS expression as well as SYT7 is unaffected. (B) Effect of siRNA-induced downregulation of SYT8 expression on INS secretion following glucose addition. (C) Schematic representation of the effect of glucose on INS– SYT8 contact and SYT8 expression (Adapted with permission from Ref. [23]).