TABLE 1.

Effect of age on tissue concentrations of total (pmol/g) and labeled phylloquinone (%) in young (4 mo) and old (20 mo) C57BL/6 male mice¹

	Total phylloquinone, pmol/g			Labeled phylloquinone, %
Tissue	Young	Old	P 2	Young	Old	P 2
Kidney	14.1 ± 2.33	17.4 ± 1.97	0.30	78.4 ± 6.48	70.5 ± 3.76	0.31
Liver	16.4 ± 1.44	25.0 ± 2.42	0.005	48.1 ± 5.00	21.3 ± 4.83	<0.001
Intestine	18.1 ± 4.76	9.78 ± 2.11	0.11	85.9 ± 6.37	61.4 ± 6.23	0.01
Brain3	ND	ND		ND	ND

¹Data presented as mean ± SEM, n = 16 per group.

²Significances at P < 0.05.

³ND, not detectable; concentration was below lower limit of detection for PK and MK4 (Lower Limit of Detection = 0.01 pmol/g).