TABLE 2.

Effect of atorvastatin on tissue concentrations of total (pmol/g) and labeled MK4 (%) in C57BL/6 male mice¹

	Total MK4, pmol/g			Labeled MK4, %
Tissue	Statin +	Statin −	P 2	Statin +	Statin −	P 2
Kidney	13.8 ± 2.65	23.4 ± 3.95	0.05	20.7 ± 3.8	35.7 ± 3.2	0.008
Liver3	ND	ND		ND	ND
Intestine	2.88 ± 0.81	3.62 ± 0.74	0.51	22.9 ± 5.6	24.7 ± 3.5	0.78
Brain	13.9 ± 1.49	19.7 ± 1.75	0.31	19.8 ± 3.5	19.7 ± 1.8	0.96

¹Data presented as mean ± SEM, n = 16 per group.

²Significances at P < 0.05.

³ND, not detectable; concentration was below lower limit of detection for PK and MK4 (Lower Limit of Detection = 0.01 pmol/g).