TABLE 6.
Experiment 1: variables predictive of end-of-study prostate and baseline plasma carotenoid concentrations in men with prostate cancer consuming tomato-soy juice1
| Tissue carotenoid concentration outcome | Transformation | Model adjusted R2 | Model P value | Variable | β ± SE | P value for variable | Estimated proportion of response variability attributable to variable2 |
|---|---|---|---|---|---|---|---|
| Prostate | |||||||
| Lycopene, nmol/g | None | 0.276 | 0.004 | Constant3 | 0.421 ± 0.108 | <0.001 | — |
| — | — | — | — | Diet group (cans/d) | 0.187 ± 0.086 | 0.04 | 1.2% |
| — | — | — | — | BCO1 rs12934922 genotype | 0.211 ± 0.086 | 0.02 | 4.2% |
| — | — | — | — | BCO1 rs12934922 genotype × diet group | −0.129 ± 0.073 | 0.09 | 4% |
| — | — | — | — | BCO1 rs6564851 genotype | −0.097 ± 0.049 | 0.053 | 1.9% |
| — | — | — | — | Baseline plasma lycopene (nmol/mg LDL cholesterol) | 3.27 ± 0.979 | <0.01 | 16.3% |
| β-carotene, nmol/g | None | 0.343 | 0.001 | Constant | −0.024 ± 0.070 | 0.737 | — |
| — | — | — | — | Diet group | 0.143 ± 0.050 | <0.01 | 0% |
| — | — | — | — | Body mass | −0.003 ± 0.001 | 0.03 | 7% |
| — | — | — | — | Baseline plasma β-carotene (umol/L)* | 0.173 ± 0.047 | <0.001 | 28% |
| — | — | — | — | BCO1 rs12934922 genotype | 0.147 ± 0.052 | <0.01 | 0% |
| — | — | — | — | BCO1 rs12934922 genotype × diet group | −0.108 ± 0.042 | 0.01 | 10% |
| — | — | — | — | BCO1 rs7501331 genotype | −0.093 ± 0.039 | 0.02 | 5% |
| Phytoene, nmol/g | None | — | — | No significant predictors | — | — | |
| Phytofluene, nmol/g | Log10 | 0.343 | <0.001 | Constant | −0.063 ± 0.149 | 0.68 | — |
| — | — | — | — | Diet group | −0.058 ± 0.054 | 0.30 | 0% |
| — | — | — | — | ABCA1 rs2230808 | −0.111 ± 0.100 | 0.28 | 0% |
| — | — | — | — | ABCA1 rs2230808 × diet group | 0.153 ± 0.07 | 0.04 | 6% |
| — | — | — | — | Log10 [Baseline plasma phytofluene (µmol/L)] (difference from mean) | 0.671 ± 0.149 | <0.001 | 33% |
| Baseline plasma | |||||||
| Lycopene, nmol/mg LDL cholesterol | None | 0.257 | 0.005 | Constant | 0.094 ± 0.022 | <0.001 | — |
| — | — | — | — | Usual daily lycopene intake (mg/d) | 0.003 ± 0.002 | 0.13 | 11% |
| — | — | — | — | BCO1 rs12934922 genotype | 0.013 ± 0.016 | 0.42 | 6.6% |
| — | — | — | — | BCO1 rs12934922 genotype × usual daily lycopene intake | −0.003 ± 0.002 | 0.07 | 7.3% |
| — | — | — | — | ABCA1 rs2230808 genotype | −0.024 ± 0.014 | 0.10 | 0% |
| — | — | — | — | ABCA1 rs2230808 genotype × usual daily lycopene intake | 0.002 ± 0.001 | 0.08 | 4.3% |
| β-carotene, µmol/L | Log10 | — | — | No significant predictors | — | — | |
| Phytoene, nmol/mg total cholesterol | Log10 | 0.138 | 0.026 | Constant | −2.186 ± 0.060 | <0.001 | — |
| — | — | — | — | Usual daily phytoene intake (mg/d) | 0.037 ± 0.026 | 0.17 | 0% |
| — | — | — | — | BCO1 rs7501331 genotype | 0.026 ± 0.079 | 0.74 | 7.2% |
| — | — | — | — | BCO1 rs7501331 genotype × usual daily phytoene intake | −0.091 ± 0.041 | 0.03 | 10.5% |
| Phytofluene, µmol/L | Log10 | 0.131 | 0.018 | Constant | −0.663 ± 0.126 | <0.001 | — |
| — | — | — | — | Usual daily phytofluene intake | 0.108 ± 0.049 | 0.04 | 7.6% |
| — | — | — | — | SCARB1 rs11057841 genotype | −0.128 ± 0.066 | 0.06 | 5.5% |
1 ABCB1, ATP-binding cassette subfamily B member 1; BCO1, β-carotene 15,15’ monooxygenase 1; SCARB1, scavenger receptor class B type 1.
2As determined by stepwise removal of variables and quantifying the contribution of the variable to the model's adjusted R2. See Supplemental Figure 3 for graphical depiction of the proportion of variance in the outcome explained by each variable.
3“Constant” represents the y-intercept for the model.