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Structure of rituximab, a chimeric monoclonal antibody (~30% mouse origin and ~70% human origin).
Notes: The murine variable regions bind specifically to the CD20 antigen on malignant (as well as normal) B cells. The human constant regions allow human effector mechanisms.
Abbreviations: VL, variable domain (light chain); VH, variable domain (heavy chain); CL, constant domain (light chain); CH, constant domain (heavy chain).
