Figure 3.

Cav1 acts both as a suppressor and a promoter in breast cancer cell tumorigenesis.

Notes: Cav1 can act as a suppressor in breast cancer cell carcinogenic process via suppressing breast cancer cell proliferation, autophagy, invasion and migration and promoting apoptosis. Cav1 can also act as a promoter in breast cancer cell carcinogenic process via promoting breast cancer cell proliferation, autophagy, invasion, migration and metastasis, and suppressing apoptosis and anoikis.

Abbreviations: BKCa, large conductance Ca²⁺-activated potassium; Cav1, caveolin-1; CSF1, colony-stimulating factor 1; EMT, epithelial to mesenchymal transition; FSP-1, fibroblast-specific protein-1; HER2, human epidermal growth factor receptor-2; HSP90, heat shock protein 90; MMP, matrix metalloproteinase; MT4-MMP, membrane type 4 matrix metalloproteinase; VEGF, vascular endothelial growth factor; SDF-1, stromal cell-derived factor-1.