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. 2019 Feb 25;10:332. doi: 10.3389/fmicb.2019.00332

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Copyright © 2019 Butini, Abbandonato, Di Rienzo, Trampuz and Di Luca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isothermal microcalorimetry evaluation of antimicrobial activity of daptomycin, fosfomycin, vancomycin, trimethoprim/sulfamethoxazole, linezolid, and rifampicin against biofilm MSSA. Numbers represent antibiotic concentrations (μg/ml). A negative control has been used to confirm medium sterility (NC). Trimethoprim/sulfamethoxazole concentrations are expressed as the trimethoprim concentrations. Circled values represent the MBBC. Representative data of replicated experiments are reported.