Table 2.
Association between prognostic factors and overall survival of pediatric AML patients in the multivariable Cox proportional hazards model stratified by year of diagnosis, SEER data, 1973–2011.
| Variables | aHRa (95% CI*) | p-value |
|---|---|---|
| Age at diagnosis (years) | ||
| <10 | - | - |
| 10–19 | 1.30 (1.17,1.44) | <0.0001 |
| Sex | ||
| Female | - | - |
| Male | 1.02 (0.93, 1.13) | 0.66 |
| Race-ethnicity | ||
| Caucasian | - | - |
| Hispanics | 1.15 (1.00, 1.32) | 0.05 |
| AA | 1.27 (1.09, 1.48) | 0.002 |
| Number of primaries | ||
| 1 | - | - |
| ≥2 | 1.11 (0.88, 1.40) | 0.39 |
| Radiation | ||
| No | - | - |
| Yes | 0.94 (0.81, 1.10) | 0.44 |
| Subtype | ||
| APL | - | - |
| AML-NOS | 1.77 (1.45, 2.15) | <0.0001 |
| AEL | 2.34 (1.60, 3.40) | <0.0001 |
| AMML | 1.96 (1.54, 2.49) | <0.0001 |
| AML inv(16) | 0.48 (0.21, 1.10) | 0.08 |
| AML min diff | 2.44 (1.78, 3.35) | <0.0001 |
| AML w/o mat | 1.87 (1.35, 2.59) | 0.0002 |
| AML w/mat | 1.27 (0.94, 1.72) | 0.13 |
| AML-MRC | 1.58 (0.82, 3.02) | 0.17 |
| AML t(8) | 1.08 (0.64, 1.82) | 0.79 |
| AML t(9) | 1.80 (0.99, 3.27) | 0.06 |
| AMKL | 1.83 (1.39, 2.42) | <0.0001 |
| t-AML | 3.77 (2.20, 6.45) | <0.0001 |
| Geographic region | ||
| East | - | - |
| Pacific Coast | 1.15 (1.01, 1.32) | 0.03 |
| Northern Plains | 1.08 (0.92, 1.26) | 0.38 |
| Southwest | 1.28 (1.06, 1.54) | 0.01 |
| Percent families below poverty | ||
| Quartile 1 | - | - |
| Quartile 2 | 0.97 (0.85, 1.11) | 0.65 |
| Quartile 3 | 0.98 (0.86, 1.13) | 0.82 |
| Quartile 4 | 1.19 (1.02, 1.39) | 0.03 |
*
CI: confidence interval.
a
aHR: adjusted hazard ratio.